{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:13:48Z","timestamp":1772118828371,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/Purpose<\/jats:title>\n                    <jats:p>Adequate image registration of anatomical and functional magnetic resonance imaging (MRI) scans is necessary for MR\u2010guided head and neck cancer (HNC) adaptive radiotherapy planning. Despite the quantitative capabilities of diffusion\u2010weighted imaging (DWI) MRI for treatment plan adaptation, geometric distortion remains a considerable limitation. Therefore, we systematically investigated various deformable image registration (DIR) methods to co\u2010register DWI and T2\u2010weighted (T2W) images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials\/Methods<\/jats:title>\n                    <jats:p>We compared three commercial (ADMIRE, Velocity, Raystation) and three open\u2010source (Elastix with default settings [Elastix Default], Elastix with parameter set 23 [Elastix 23], Demons) post\u2010acquisition DIR methods applied to T2W and DWI MRI images acquired during the same imaging session in twenty immobilized HNC patients. In addition, we used the non\u2010registered images (None) as a control comparator. Ground\u2010truth segmentations of radiotherapy structures (tumour and organs at risk) were generated by a physician expert on both image sequences. For each registration approach, structures were propagated from T2W to DWI images. These propagated structures were then compared with ground\u2010truth DWI structures using the Dice similarity coefficient and mean surface distance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      19 left submandibular glands, 18 right submandibular glands, 20\u00a0left parotid glands, 20 right parotid glands, 20 spinal cords, and 12 tumours were delineated. Most DIR methods took &lt;30\u00a0s to execute per case, with the exception of Elastix 23 which took \u223c458\u00a0s to execute per case. ADMIRE and Elastix 23 demonstrated improved performance over None for all metrics and structures (Bonferroni\u2010corrected\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05), while the other methods did not. Moreover, ADMIRE and Elastix 23 significantly improved performance in individual and pooled analysis compared to all other methods.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The ADMIRE DIR method offers improved geometric performance with reasonable execution time so should be favoured for registering T2W and DWI images acquired during the same scan session in HNC patients. These results are important to ensure the appropriate selection of registration strategies for MR\u2010guided radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.16128","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T09:35:31Z","timestamp":1671096931000},"page":"2089-2099","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Quality assurance assessment of intra\u2010acquisition diffusion\u2010weighted and T2\u2010weighted magnetic resonance imaging registration and contour propagation for head and neck cancer radiotherapy"],"prefix":"10.1002","volume":"50","author":[{"given":"Mohamed A.","family":"Naser","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kareem A.","family":"Wahid","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Salama","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cem","family":"Dede","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin W.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruitao","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigid","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis C.","family":"Salzillo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renjie","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Radiation Physics The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moamen Abobakr","family":"Abdelaal","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Thill","sequence":"additional","affiliation":[{"name":"Elekta AB  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolette","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Elekta AB  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virgil","family":"Willcut","sequence":"additional","affiliation":[{"name":"Elekta AB  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Christodouleas","sequence":"additional","affiliation":[{"name":"Elekta AB  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen Y.","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clifton D.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdallah S. 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