{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:44:51Z","timestamp":1790293491892,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VR\u2010NT 2019\u201005416"],"award-info":[{"award-number":["VR\u2010NT 2019\u201005416"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["CAN 2017\/1029"],"award-info":[{"award-number":["CAN 2017\/1029"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","award":["252135"],"award-info":[{"award-number":["252135"]}],"id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Intensity\u2010modulated brachytherapy (IMBT) is an emerging technology for cancer treatment, in which radiation sources are shielded to shape the dose distribution. The rotatable shields provide an additional degree of freedom, but also introduce an additional, directional, type of uncertainty, compared to conventional high\u2010dose\u2010rate brachytherapy (HDR BT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>We propose and evaluate a robust optimization approach to mitigate the effects of rotational uncertainty in the shields with respect to planning\u00a0criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A previously suggested prototype for platinum\u2010shielded prostate\n                      <jats:sup>169<\/jats:sup>\n                      Yb\u2010based dynamic IMBT is considered. We study a retrospective patient data set (anatomical contours and catheter placement) from two clinics, consisting of six patients that had previously undergone conventional\n                      <jats:sup>192<\/jats:sup>\n                      Ir HDR BT treatment. The Monte Carlo\u2010based treatment planning software RapidBrachyMCTPS is used for dose calculations. In our computational experiments, we investigate systematic rotational shield errors of \u00b110\u00b0 and \u00b120\u00b0, and the same systematic error is applied to all dwell positions in each scenario. This gives us three scenarios, one nominal and two with errors. The robust optimization approach finds a compromise between the average and worst\u2010case scenario\u00a0outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We compare dose plans obtained from standard models and their robust counterparts. With dwell times obtained from a linear penalty model (LPM), for 10\u00b0 errors, the dose to urethra () and rectum ( and ) increase with up to 5% and 7%, respectively, in the worst\u2010case scenario, while with the robust counterpart, the corresponding increases were 3% and 3%. For all patients and all evaluated criteria, the worst\u2010case scenario outcome with the robust approach had lower deviation compared to the standard model, without compromising target coverage. We also evaluated shield errors up to 20\u00b0 and while the deviations increased to a large extent with the standard models, the robust models were capable of handling even such large\u00a0errors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We conclude that robust optimization can be used to mitigate the effects from rotational uncertainty and to ensure the treatment plan quality of\u00a0IMBT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.16134","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T17:31:56Z","timestamp":1670434316000},"page":"1029-1043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dosimetric impact of a robust optimization approach to mitigate effects from rotational uncertainty in prostate intensity\u2010modulated brachytherapy"],"prefix":"10.1002","volume":"50","author":[{"given":"Bj\u00f6rn","family":"Mor\u00e9n","sequence":"first","affiliation":[{"name":"Department of Mathematics Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majd","family":"Antaki","sequence":"additional","affiliation":[{"name":"Department of Oncology Medical Physics Unit McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Famulari","sequence":"additional","affiliation":[{"name":"Department of Oncology Medical Physics Unit McGill University Montreal QC Canada"},{"name":"D\u00e9partement de Radio\u2010oncologie Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Morcos","sequence":"additional","affiliation":[{"name":"Department of Oncology Medical Physics Unit McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f6rn","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Mathematics Link\u00f6ping University Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin A.","family":"Enger","sequence":"additional","affiliation":[{"name":"Department of Oncology Medical Physics Unit McGill University Montreal QC Canada"},{"name":"Lady Davis Institute for Medical Research Jewish General Hospital Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c5sa Carlsson","family":"Tedgren","sequence":"additional","affiliation":[{"name":"Radiation Physics Department of Health, Medicine and Caring Sciences Link\u00f6ping University Link\u00f6ping Sweden"},{"name":"Medical Radiation Physics and Nuclear Medicine Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Oncology Pathology Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/47\/14\/309"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.07.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2021.08.004"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14802"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.12111"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/40\/5\/003"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596813"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90116-3"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/4\/957"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2017.09.028"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2011.09.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.05.002"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2021.12.047"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brachy.2011.07.002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13959"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4870441"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14459"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.1368127"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.2349685"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3676179"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aaab83"},{"key":"e_1_2_9_23_1","unstructured":"Beli\u00ebnJ ColpaertJ De BoeckL DemeulemeesterE.A hybrid simulated annealing linear programming approach for treatment planning in HDR brachytherapy with dose volume constraints. InProceedings of the 35th International Conference on Operational Research Applied to Health Services (ORAHS).2009."},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3598437"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/4\/1041"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/61\/3\/1155"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12410"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13533"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ab4d8d"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.14762"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2019.04.009"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3456598"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4769416"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4897617"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12486"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aba317"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aae659"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1287\/ijoc.2018.0815"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-58115-2_31"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.11.002"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9002(03)01368-8"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1109\/TNS.2006.869826"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aad97a"},{"key":"e_1_2_9_44_1","unstructured":"GlickmanH AntakiM DeufelC EngerSA.RapidBrachyMCTPS 2.0: a comprehensive and flexible Monte Carlo\u2010based treatment planning system for brachytherapy applications.arXiv preprint arXiv:2007.02902.2020."},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12702"},{"key":"e_1_2_9_46_1","volume-title":"Gurobi Optimizer Reference Manual","author":"Gurobi Optimization LLC","year":"2022"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.04.045"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598418"},{"key":"e_1_2_9_49_1","doi-asserted-by":"crossref","unstructured":"TulliJK.Evaluated Nuclear Structure Data File A Manual for Preparation of Data Sets. Technical Report.2001.","DOI":"10.2172\/779777"},{"key":"e_1_2_9_50_1","doi-asserted-by":"crossref","unstructured":"CullenD HubbellJ KisselL.EPDL97:The Evaluated Photon Data Library.1997;6.","DOI":"10.2172\/295438"},{"key":"e_1_2_9_51_1","first-page":"500","article-title":"Tables and Graphs of Electron\u2010interaction Cross Sections from 10 eV to 100 GeV derived from the LLNL Evaluated Electron Data Library (EEDL), Z = 1\u2013100","volume":"31","author":"Perkins ST","year":"1991","journal-title":"Uclr\u201350400"},{"key":"e_1_2_9_52_1","doi-asserted-by":"crossref","unstructured":"PerkinsST CullenD ChenMH RathkopfJ ScofieldJ HubbellJH.Tables and Graphs of Atomic Subshell and Relaxation Data Derived from the LLNL Evaluated Atomic Data Library (EADL) Z = 1\u2013100.UCRL\u201050400.US Department of Energy Office of Scientific and Technical Information;1991.","DOI":"10.2172\/10121422"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596069"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.01.007"}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mp.16134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mp.16134","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mp.16134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T20:24:55Z","timestamp":1692563095000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/mp.16134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,29]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/mp.16134"],"URL":"https:\/\/doi.org\/10.1002\/mp.16134","archive":["Portico"],"relation":{},"ISSN":["0094-2405","2473-4209"],"issn-type":[{"value":"0094-2405","type":"print"},{"value":"2473-4209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,29]]},"assertion":[{"value":"2022-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}