{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:27:26Z","timestamp":1787592446754,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12072214"],"award-info":[{"award-number":["12072214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>It was still controversial that whether the increase of splenic vein (SV) diameter increased the risk of portal vein thrombosis (PVT), which was a severe disease with high mortality, in the clinic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purposes<\/jats:title><jats:p>This study, using computational fluid dynamics method, aimed to investigate how the increase of SV diameter affects the portal vein hemodynamics under different anatomical and geometric features of the portal venous system, thus how it induced to PVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ideal models of the portal system, including different anatomical structures according to the location of left gastric vein (LGV) and inferior mesenteric vein (IMV), and different geometric morphological parameters models were established to carry out numerical simulation in this study. In addition, the morphological parameters of real patients were measured to verify the numerical simulation results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>First, the wall shear stress (WSS) and helicity intensity, which were closely related to the occurrence of thrombosis, gradually decreased with the increase of SV diameter in all models. However, the degree of decrease was bigger in following models: (1) the models with LGV and IMV linking to SV compared with them linking to PV; (2) the models with big angle of PV and SV compared with small angle. In addition, the morbidity of PVT was higher when LGV and IMV linked to SV rather than them linked to PV in the real patients. Moreover, the angle of PV and SV was also different between PVT and non\u2010PVT patients (125.53\u00b0\u00a0\u00b1\u00a016.90\u00b0 vs. 115.03\u00b0\u00a0\u00b1\u00a016.10\u00b0, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Whether the increase of SV diameter will result in PVT is depended on the anatomical structure of portal system and the angle between PV and SV, this is also the reason leading to the clinical controversy that the increase of SV diameter is the risk factor of PVT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.16481","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T15:14:49Z","timestamp":1685027689000},"page":"6614-6623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of splenic vein diameter on the diagnosis of portal vein thrombosis"],"prefix":"10.1002","volume":"50","author":[{"given":"Zhuxiang","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Applied Mechanics Sichuan University  Chengdu China"},{"name":"Sichuan University Yibin Park\/Yibin Institute of Industrial Technology  Yibin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoze","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Applied Mechanics Sichuan University  Chengdu China"},{"name":"Sichuan University Yibin Park\/Yibin Institute of Industrial Technology  Yibin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinghui","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Applied Mechanics Sichuan University  Chengdu China"},{"name":"Sichuan University Yibin Park\/Yibin Institute of Industrial Technology  Yibin China"},{"name":"West China Information Center Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.4326"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-020-04624-4"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112316"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jceh.2014.12.008"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.01.265"},{"issue":"3","key":"e_1_2_10_7_1","first-page":"315","article-title":"Portal vein thrombosis in cirrhosis: diagnosis, natural history, and therapeutic challenges","volume":"31","author":"Mantaka A","year":"2018","journal-title":"Ann Gastroenterol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.04.029"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i18.3279"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.909403"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000229658.76797.30"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-1097-2"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-20-4912"},{"key":"e_1_2_10_14_1","first-page":"27","article-title":"Nomogram model for prediction of portal vein thrombosis in patients with liver cirrhosis after splenectomy: a retrospective analysis of 2 independent cohorts","author":"Yuan HL","year":"2021","journal-title":"Med Sci Monit"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-020-02044-1"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-020-02751-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-015-1592-7"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12246"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.661030"},{"issue":"1","key":"e_1_2_10_20_1","first-page":"S233","article-title":"Computational hemodynamics of portal vein hypertension in hepatic cirrhosis patients","volume":"26","author":"Li X","year":"2015","journal-title":"Biomed Mater Eng"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10237-020-01320-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2016.03.025"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-022-01330-4"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.06.026"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13239-014-0195-5"},{"issue":"12","key":"e_1_2_10_26_1","article-title":"Fluid\u2010structure interaction simulation of an intra\u2010atrial Fontan connection","volume":"9","author":"Tang E","year":"2020","journal-title":"Biology (Basel)"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-014-1119-0"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000080882.35274.AD"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2019.10.019"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvsv.2012.08.002"}],"container-title":["Medical Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mp.16481","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T05:43:19Z","timestamp":1697089399000},"score":1,"resource":{"primary":{"URL":"https:\/\/aapm.onlinelibrary.wiley.com\/doi\/10.1002\/mp.16481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,25]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/mp.16481"],"URL":"https:\/\/doi.org\/10.1002\/mp.16481","archive":["Portico"],"relation":{},"ISSN":["0094-2405","2473-4209"],"issn-type":[{"value":"0094-2405","type":"print"},{"value":"2473-4209","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,25]]},"assertion":[{"value":"2022-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}