{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:11Z","timestamp":1786978211481,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST109\u20102314\u2010B\u2010010\u2010026"],"award-info":[{"award-number":["MOST109\u20102314\u2010B\u2010010\u2010026"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["MOST 111\u20102221\u2010E\u2010A49\u2010060"],"award-info":[{"award-number":["MOST 111\u20102221\u2010E\u2010A49\u2010060"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["YC\u2010Y21C078"],"award-info":[{"award-number":["YC\u2010Y21C078"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Transmission\u2010target x\u2010ray tubes generate more x\u2010rays than reflection thick\u2010target x\u2010ray tubes. A transmission x\u2010ray tube combined with radiosensitizers has a better radiation enhancement effect. This study investigated the feasibility of using a transmission x\u2010ray tube with radiosensitizers in clinical radiotherapy and its effect on radiation dose enhancement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study used MCNP6.2 to simulate the model of a transmission x\u2010ray tube and Co\u201060 beam.\u00a0\u00a0 The radiation enhancement effect of radiosensitizers was examined with iodine\u2010127 (I\u2010127), radioiodinated iododeoxyuridine (IUdR), and gold nanoparticles (GNPs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study results showed that the dose enhancement factor (DEF) of the transmission x\u2010ray tube with GNPs was 10.27, which was higher than that of I\u2010127 (6.46) and IUdR (3.08). The DEF of the Co\u201060 beam with GNPs, I\u2010127, and IUdR was 1.23, 1.19, and 1.2, respectively. The Auger electron flux of the transmission x\u2010ray tube with GNPs was 1.19E+05 particles\/cm\n                      <jats:sup>2<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study found that a transmission x\u2010ray tube with appropriate radiosensitizers could produce a high rate of Auger electrons to fulfill the radiation enhancement effect, and this procedure has the potential to become a radiotherapy modality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.16678","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T08:55:03Z","timestamp":1693558503000},"page":"8057-8062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Technical note: Evaluation of the dose enhancement effect for a 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