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Some radionuclides emit hard x\u2010rays and gamma\u2010rays below 100 keV, in which energy range the performance of conventional NaI scintillators is poor. Multipinhole collimators are also used for small animal imaging with a good spatial resolution but have a limited field of view (FOV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>In this study, a new imager with high sensitivity over a wide FOV in the low\u2010energy band (100 keV) was developed for the pharmacokinetic\u00a0study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We developed an x\u2010ray and gamma\u2010ray camera for high\u2010resolution spectroscopy, named \u201cCdTe XG\u2010Cam,\u201d equipped with a cadmium telluride semiconductor detector and a parallel\u2010hole collimator using a metal 3D printer. To evaluate the camera\u2010system performance, phantom measurements with single and dual nuclides (, , and  were performed. The performance for in vivo imaging was evaluated using tumor\u2010bearing mice to which a nuclide ( or \u00a0administered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We simultaneously obtained information on  and , which emit emission lines in the low\u2010energy band with peak energies close to each other (23\u201326 keV for  and 27\u201331 keV for , and applied an analytical method based on spectral model fitting to determine the individual radioactivities accurately. In the small animal imaging, the distributions of the nuclide in tumors were accurately quantified and time\u2010activity curves in tumors are\u00a0obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The demonstrated capability of our system to perform in vivo imaging suggests that the camera can be used for applications of pharmacokinetics\u00a0research.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.17124","type":"journal-article","created":{"date-parts":[[2024,5,19]],"date-time":"2024-05-19T18:38:47Z","timestamp":1716143927000},"page":"5308-5320","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["CdTe XG\u2010Cam: A new high\u2010resolution x\u2010ray and gamma\u2010ray camera for studies of the pharmacokinetics of radiopharmaceuticals in small animals"],"prefix":"10.1002","volume":"51","author":[{"given":"Miho","family":"Katsuragawa","sequence":"first","affiliation":[{"name":"Kavli Institute for the Physics and Mathematics of the Universe (IPMU) (WPI), The University of Tokyo Institutes for Advanced Study (UTIAS) The University of Tokyo Kashiwa Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Yagishita","sequence":"additional","affiliation":[{"name":"Kavli Institute for the Physics and Mathematics of the Universe (IPMU) (WPI), The University of Tokyo Institutes for Advanced Study (UTIAS) The University of Tokyo Kashiwa Chiba Japan"},{"name":"iMAGINE\u2010X Inc. Shibuya\u2010ku Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin'ichiro","family":"Takeda","sequence":"additional","affiliation":[{"name":"Kavli Institute for the Physics and Mathematics of the Universe (IPMU) (WPI), The University of Tokyo Institutes for Advanced Study (UTIAS) The University of Tokyo Kashiwa Chiba Japan"},{"name":"iMAGINE\u2010X Inc. 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