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Voxel DR distributions and LET spectra at planning target margins are paramount to the DR\/LET\u2010related sparing of organs at risk. We hereby present a methodology to achieve experimental validation of these parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dose, DR, and LET were measured for a conformal FLASH treatment plan involving a 250\u2010MeV proton beam and a 3D\u2010printed ridge filter designed to uniformly irradiate a spherical target. We measured dose and DR simultaneously using a 4D multi\u2010layer strip ionization chamber (MLSIC) under UHDR conditions. Additionally, we developed an \u201c<jats:styled-content>u<\/jats:styled-content>nder\u2010<jats:styled-content>s<\/jats:styled-content>ample and <jats:styled-content>re<\/jats:styled-content>cover (USRe)\u201d technique for a high\u2010resolution pixelated semiconductor detector, Timepix3, to avoid event pile\u2010up and to correct measured LET at high\u2010proton\u2010flux locations without undesirable beam modifications. Confirmation of these measurements was done using a MatriXX PT detector and by Monte Carlo (MC) simulations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MC conformal FLASH computed doses had gamma passing rates of\u00a0&gt;95% (3\u00a0mm\/3% criteria) when compared to MatriXX PT and MLSIC data. At the lateral margin, DR showed average agreement values within 0.3% of simulation at 100\u00a0Gy\/s and fluctuations \u223c10% at 15\u00a0Gy\/s. LET spectra in the proximal, lateral, and distal margins had Bhattacharyya distances of\u00a0&lt;1.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our measurements with the MLSIC and Timepix3 detectors shown that the DR distributions for UHDR scenarios and LET spectra using USRe are in agreement with simulations. These results demonstrate that the methodology presented here can be used effectively for the experimental validation and QA of FLASH treatment plans.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mp.17359","type":"journal-article","created":{"date-parts":[[2024,8,17]],"date-time":"2024-08-17T20:43:23Z","timestamp":1723927403000},"page":"8411-8422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterizing devices for validation of dose, dose rate, and LET in ultra high dose rate proton irradiations"],"prefix":"10.1002","volume":"51","author":[{"given":"Nathan","family":"Harrison","sequence":"first","affiliation":[{"name":"Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Charyyev","sequence":"additional","affiliation":[{"name":"Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Oancea","sequence":"additional","affiliation":[{"name":"ADVACAM s.r.o.  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