{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:39:59Z","timestamp":1777945199931,"version":"3.51.4"},"reference-count":55,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T00:00:00Z","timestamp":1739232000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EB029443"],"award-info":[{"award-number":["R01 EB029443"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R03 EB029078"],"award-info":[{"award-number":["R03 EB029078"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The nuclear Overhauser enhancement (NOE)\u2010mediated saturation transfer effect at \u20101.6\u00a0ppm, termed NOE(\u20101.6\u00a0ppm), has demonstrated potential for detecting ischemic stroke. However, the quantification of the NOE(\u20101.6\u00a0ppm) effect usually relies on a multiple\u2010pool Lorentzian fit method, which necessitates a time\u2010consuming acquisition of the entire chemical exchange saturation transfer (CEST) Z\u2010spectrum with high\u2010frequency resolution, thus hindering its clinical applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aims to assess the feasibility of employing asymmetry analysis, a rapid CEST data acquisition and analysis method, for quantifying the NOE(\u20101.6\u00a0ppm) effect in an animal model of ischemic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We examined potential contaminations from guanidinium\/amine CEST, NOE(\u20103.5\u00a0ppm), and asymmetric magnetization transfer (MT) effects, which could reduce the specificity of the asymmetry analysis of NOE(\u20101.6\u00a0ppm). First, a Lorentzian difference (LD) analysis was used to mitigate direct water saturation and MT effects, providing separate estimations of the contributions from the guanidinium\/amine CEST and NOE effects. Then, the asymmetry analysis of the LD fitted spectrum was compared with the asymmetry analysis of the raw CEST Z\u2010spectrum to evaluate the contribution of the asymmetric MT effect at \u20101.6\u00a0ppm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results show that the variations of the LD quantified NOE(\u20101.6\u00a0ppm) in stroke lesions are much greater than that of the CEST signals at +1.6\u00a0ppm and NOE(\u20103.5\u00a0ppm), suggesting that NOE(\u20101.6\u00a0ppm) has a dominating contribution to the asymmetry analysis at \u20101.6\u00a0ppm compared with the guanidinium\/amine CEST and NOE(\u20103.5\u00a0ppm) in ischemic stroke. The NOE(\u20101.6\u00a0ppm) variations in the asymmetry analysis of the raw CEST Z\u2010spectrum are close to those in the asymmetry analysis of the LD fitted spectrum, revealing that the NOE(\u20101.6\u00a0ppm) dominates over the asymmetric MT effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrates that the asymmetry analysis can quantify the NOE(\u20101.6\u00a0ppm) contrast in ischemic stroke with high specificity, thus presenting a viable alternative for rapid mapping of ischemic stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.17677","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T22:12:26Z","timestamp":1739311946000},"page":"2922-2937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Asymmetry analysis of nuclear Overhauser enhancement effect at \u20101.6\u00a0ppm in ischemic stroke"],"prefix":"10.1002","volume":"52","author":[{"given":"Yu","family":"Zhao","sequence":"first","affiliation":[{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville USA"},{"name":"Department of Radiology and Functional and Molecular Imaging Key Laboratory of Sichuan Province West China Hospital of Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aqeela","family":"Afzal","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Vanderbilt University Medical Center  Nashville USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongliang","family":"Zu","sequence":"additional","affiliation":[{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt 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