{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:17:02Z","timestamp":1778692622470,"version":"3.51.4"},"reference-count":53,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evaluating regional variations in right ventricular (RV) performance can be challenging, particularly in patients with significant impairments due to the need for 3D spatial coverage with high spatial resolution. ECG\u2010gated cineCT can fully visualize the RV and be used to quantify regional strain with high spatial resolution. However, strain is influenced by loading conditions. Myocardial work (MW)\u2014measured clinically as the ventricular pressure\u2010strain loop area\u2014is considered a more comprehensive metric due to its independence of preload and afterload. In this study, we sought to develop regional RV MW assessments in 3D with high spatial resolution by combining cineCT\u2010derived regional strain with RV pressure waveforms from right heart catheterization (RHC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Regional MW is not measured in the right ventricle (RV) due to a lack of high spatial resolution regional strain (RS) estimates throughout the ventricle. We present a cineCT\u2010based approach to evaluate regional RV performance and demonstrate its ability to phenotype three complex populations: end\u2010stage LV failure (HF), chronic thromboembolic pulmonary hypertension (CTEPH), and repaired tetralogy of Fallot (rTOF).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty\u2010nine patients (19 HF, 11 CTEPH, 19 rTOF) underwent cineCT and RHC. RS was estimated as the regional change in the endocardial surface from full\u2010cycle ECG\u2010gated cineCT and combined with RHC pressure waveforms to create regional pressure\u2010strain loops; endocardial MW was measured as the loop area. Detailed, 3D mapping of RS and MW enabled spatial visualization of strain and work strength, and phenotyping of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HF patients demonstrated more overall impaired strain and work compared to the CTEPH and rTOF cohorts. For example, the HF patients had more akinetic areas (median: 9%) than CTEPH (median:\u00a0&lt;\u00a01%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) and rTOF (median: 1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01) and performed more low work (median: 69%) than the rTOF cohort (median: 38%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01). The CTEPH cohort had more impairment in the septal wall;\u00a0&lt;\u00a01% of the free wall and 16% of the septal wall performed negative work. The rTOF cohort demonstrated a wide distribution of strain and work, ranging from hypokinetic to hyperkinetic strain and low to medium\u2010high work. Impaired strain (\u20100.15\u00a0\u2264\u00a0RS) and negative work were strongly\u2010to\u2010very strongly correlated with RVEF (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u20100.89,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01;\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u20100.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01, respectively), while impaired work (MW\u00a0\u2264\u00a05\u00a0mmHg) was moderately correlated with RVEF (\n                      <jats:italic>R<\/jats:italic>\n                      \u00a0=\u00a0\u20100.53,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Regional RV MW maps can be derived from clinical CT and RHC studies and can provide patient\u2010specific phenotyping of RV function in complex heart disease patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.17738","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:38:14Z","timestamp":1742359094000},"page":"4205-4221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Three\u2010dimensional regional evaluation of right ventricular myocardial work from cine computed tomography: A pilot study"],"prefix":"10.1002","volume":"52","author":[{"given":"Amanda","family":"Craine","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhruvi","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seth","family":"Kligerman","sequence":"additional","affiliation":[{"name":"Department of Radiology National Jewish Health  Denver Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Adler","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine University of California San Diego  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nick H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care, Sleep Medicine &amp; 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