{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T10:34:43Z","timestamp":1765190083695,"version":"3.46.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R61AT012282","R01HL174570","R01CA237277"],"award-info":[{"award-number":["R61AT012282","R01HL174570","R01CA237277"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Available studies on chronic lower back pain (cLBP) typically focus on one or a few specific tissues rather than conducting a comprehensive layer\u2010by\u2010layer analysis. Since three\u2010dimensional (3\u2010D) images often contain hundreds of slices, manual annotation of these anatomical structures is both time\u2010consuming and error\u2010prone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aim to develop and validate a novel approach called InterSliceBoost to enable the training of a segmentation model on a partially annotated dataset without compromising segmentation performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      The architecture of InterSliceBoost includes two components: an inter\u2010slice generator and a segmentation model. The generator utilizes residual block\u2010based encoders to extract features from adjacent image\u2010mask pairs (IMPs). Differential features are calculated and input into a decoder to generate inter\u2010slice IMPs. The segmentation model is trained on partially annotated datasets (e.g., skipping 1, 2, 3, or 7 images) and the generated inter\u2010slice IMPs. To validate the performance of InterSliceBoost, we utilized a dataset of 76 B\u2010mode ultrasound scans acquired on 29 subjects enrolled in an ongoing cLBP study. An ultrasound operator annotated six anatomical layers across all image slices (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a018\u00a0986), including dermis, superficial fat, superficial fascial membrane (SFM), deep fat, deep fascial membrane (DFM), and muscle. The mean Dice coefficient across all tissue layer was used as the primary performance metric. A paired sample t\u2010test with Bonferroni correction was conducted to assess the significance of performance differences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      InterSliceBoost, trained on only 33% of the image slices, achieved a mean Dice coefficient of 80.84% across all six layers on the independent test set, with Dice coefficients of 73.48%, 61.11%, 81.87%, 95.74%, 83.52%, and 88.74% for segmenting dermis, superficial fat, SFM, deep fat, DFM, and muscle. This performance is significantly higher than the conventional model trained on fully annotated images (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>InterSliceBoost can effectively segment the six tissue layers depicted on 3\u2010D B\u2010model ultrasound images in settings with partial annotations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical relevance statement<\/jats:title>\n                    <jats:p>InterSliceBoost enables tissue layer segmentation with fewer manual annotations. By comprehensively examining each tissue layer, this approach offers deeper insights into the structural and functional characteristics that may contribute to the onset and progression of cLBP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.17931","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T02:46:22Z","timestamp":1752633982000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intersliceboost: Identifying tissue layers in three\u2010dimensional ultrasound images for chronic lower back pain (cLBP) assessment"],"prefix":"10.1002","volume":"52","author":[{"given":"Zixue","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Bioengineering University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Radiology University of Pittsburgh  Pittsburgh Pennsylvania 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