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There is thus a clinical need to accurately differentiate BPH\u2010Only from BPH\u2010PCa to prevent overdiagnosis and unnecessary biopsies. Although BPH and PCa may share overlapping features, they are distinct clinical entities. Previous evidence suggests that prostate peripheral zone (PZ) and transition zone (TZ) volumes on MRI are differentially associated in patients with BPH\u2010PCa versus those with BPH\u2010Only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop and validate the ratio of machine learning derived PZ and TZ volumes on T2\u2010weighted (T2W) MRI as an imaging biomarker to distinguish BPH\u2010PCa and BPH\u2010Only.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this single\u2010center, retrospective study, we identified\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0199 patients (106 BPH\u2010Only and 93 with both BPH\u2010PCa) who underwent a three Tesla multi\u2010parametric MRI before systematic biopsy. A radiologist and a urologist jointly annotated PZ and TZ regions of interest on T2W, involving all 199 cases. We presented and trained a 3D conditional generative adversarial network (cGAN)\u2010based prostate zone volume segmentation model (ProZonaNet) to segment 3D prostate TZ, PZ volumes on T2W MRI. We used 139 cases (with 7\u00d7 data augmentation, yielding 973 training volumes) and an independent test set of 60 cases to train and evaluate ProZonaNet. ProZonaNet was optimized in terms of dice similarity coefficient (DSC). We then computed prostate zonal volume ratio (pZVR\u00a0=\u00a0TZ\/PZ) from both ProZonaNet segmentations and ground\u2010truth annotations on all 199 cases, evaluating agreement using Concordance Correlation Coefficient (CCC). The pZVR biomarker was assessed for its ability to distinguish BPH\u2010PCa from BPH\u2010Only. Univariate and multivariate analyses were performed to evaluate the independent effect of pZVR over clinical parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      ProZonaNet achieved a mean mDICE of 92.5% on the independent test set (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a060), outperforming state\u2010of\u2010the\u2010art 3D segmentation models. The computed pZVR showed high agreement with ground\u2010truth annotations, with CCC values of 0.960 for BPH\u2010Only and 0.930 for BPH\u2010PCa cases. The pZVR computed using ProZonaNet, along with two other clinical parameters, including age and prostate\u2010specific antigen, improved the AUC from 0.758 to 0.927 in distinguishing between BPH\u2010Only and BPH\u2010PCa. At the same time, on a subset of low\u2010grade prostate cancer cases (106 BPH\u2010Only and 23 BPH\u2010PCa with Gleason Score\u00a0=\u00a03+3), the integrated pZVR model improved the AUC from 0.750 to 0.910 in distinguishing between patients with BPH\u2010Only versus BPH\u2010PCa. On both univariate and multivariate analyses, pZVR demonstrated significant discrimination between patients with BPH\u2010Only versus BPH\u2010PCa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrated that the prostate zonal volume ratio computed with our ProZonaNet can be used to differentiate benign prostatic hyperplasia from prostate cancer on MRI. These results demonstrate the feasibility of non\u2010invasive diagnosis of BPH\u2010PCa, potentially aiding in the ability to distinguish PCa from benign cancer confounders such as BPH\u2010Only.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.18053","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T04:23:57Z","timestamp":1755145437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A deep learning derived prostate zonal volume\u2010based biomarker from T2\u2010weighted MRI to distinguish between prostate cancer and benign prostatic hyperplasia"],"prefix":"10.1002","volume":"52","author":[{"given":"Zelin","family":"Zhang","sequence":"first","affiliation":[{"name":"Wallace H. 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