{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T08:10:45Z","timestamp":1772007045835,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>CT\u2010guided percutaneous lung nodule biopsy (CLNB) is a critical diagnostic tool for pulmonary lesions, yet traditional methods are limited by operator\u2010dependent variability and higher complication risks. The dual\u2010laser beam design of the laser positioning (LP) device, utilizing real\u2010time trajectory correction, holds potential to improve puncture accuracy and reduce human error, but its clinical value in CLNB remains to be systematically validated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The purpose of this study was to retrospectively assess the advanced puncture efficacy and clinical safety of the LP device during CLNB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 115 patients (61\u00b112 [SD]years; 83 women) were included in this study. All patients were allocated into two groups: one group underwent CLNB without an LP device, while the other group used an LP device during the procedure. The efficacy of the procedures was assessed based on the success rate, the adjustments number and the puncture time. Additionally, safety evaluations focused on complications associated with the percutaneous surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The success rate of the first puncture in the LP group was significantly higher than in the CLNB group [88.70%(55\/62) vs. 52.80%(28\/53),\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001]. The puncture time was significantly lower in the LP group (9.71\u00b14.20 vs. 18.21\u00b16.53\u00a0min,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). When analyzing the skin\u2010to\u2010lesion distance, categorized into two ranges of 20\u201360\u00a0mm and &gt; 60\u00a0mm, the LP group consistently required less time for the procedure (9.66\u00b15.20 vs. 16.86\u00b15.16\u00a0min,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), (9.93\u00b13.97\u00a0vs. 19.31\u00b17.39\u00a0min,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Furthermore, the incidence of complications in the LP group was significantly lower than in the CLNB group [6.45% (4\/62) vs. 50.94% (27\/53),\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The LP device improved the puncture accuracy of CLNB, shortened the operation time, and reduced the incidence of complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.18066","type":"journal-article","created":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T14:59:42Z","timestamp":1756047582000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Operational efficiency and clinical safety of laser positioning\u2010assisted CT\u2010guided lung nodule biopsy: A single\u2010center retrospective cohort study"],"prefix":"10.1002","volume":"52","author":[{"given":"Guoqiang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics General Hospital of Southern Theater Command of PLA  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology General Hospital of Southern Theater Command of PLA  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingfeng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Radiology General Hospital of Southern Theater Command of PLA  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics General Hospital of Southern Theater Command of PLA  Guangzhou People's Republic of China"},{"name":"The First School of Clinical Medicine Southern Medical University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqing","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Radiology General Hospital of Southern Theater Command of PLA  Guangzhou People's Republic of 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