{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:59:15Z","timestamp":1791381555490,"version":"4.3.3"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patient\u2010specific dosimetry in radiopharmaceutical therapy (RPT) offers a promising approach to optimize the balance between treatment efficacy and toxicity. The introduction of 360\u00b0 CZT gamma cameras enables the development of personalized dosimetry studies using whole\u2010body single photon emission computed tomography and computed tomography (SPECT\/CT) data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study proposes to validate the collapsed\u2010cone superposition (CCS) approach against Monte Carlo (MC) simulations for whole\u2010body dosimetry of [177Lu]Lu\u2010PSMA\u2010617 therapy in patients with metastatic castration resistant prostate cancer (mCRPC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>\n                      Thirty patients with mCRPC were retrospectively included in this study. SPECT\/CT images were acquired after the infusion of [177Lu]Lu\u2010PSMA\u2010617 therapy. SimpleDose was used to generate dose\u2010rate maps (mGy\/h) from a single SPECT\/CT scan. The dosimetry relies on the CCS approach, which adjusts dose\u2010point kernels according to tissue densities. Organ and lesion delineation were automated using the nnU\u2010Net V2 neural network. MC simulations were performed with GATE 10 for 10\n                      <jats:sup>8<\/jats:sup>\n                      events. To assess the impact of density\u2010scaled DPK on the accuracy of the dosimetry, we implement a simplified version of CCS, denoted as , which assumes a homogeneous soft tissue medium without incorporating the patient\u2010specific density information derived from the CT image. The comparison between CCS,  and MC was conducted at the organ, lesion, and voxel levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Absolute percentage errors (APE) between CCS and MC were &lt; 5% for all organs and lesions. Compared to CCS,  exhibited higher APE with respect to MC in the liver, lungs, salivary glands, and lesions, while lower errors were observed in the bone marrow, kidneys, and pancreas, with comparable performance in the spleen. Voxel\u2010level errors were mostly &lt; 2% for both methods CCS and . Median computation time was, respectively, 24.5\u00a0s, 46.45\u00a0s, and 6.8\u00a0h for CCS, , and MC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CCS showed high agreement with MC with greater computational efficiency, demonstrating its clinical potential for whole\u2010body dosimetry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.18076","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:39:21Z","timestamp":1756964361000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Validation of the collapsed\u2010cone superposition for whole\u2010body patient\u2010specific dosimetry in [177Lu]Lu\u2010PSMA\u2010617 radionuclide therapy"],"prefix":"10.1002","volume":"52","author":[{"given":"Aya","family":"Terro","sequence":"first","affiliation":[{"name":"QuantIF AIMS University of Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sol\u00e8ne","family":"Perret","sequence":"additional","affiliation":[{"name":"QuantIF AIMS University of Rouen  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Dumouchel","sequence":"additional","affiliation":[{"name":"QuantIF AIMS University of Rouen  Rouen France"},{"name":"Nuclear Medicine Department Henri Becquerel Center  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Tonnelet","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department Henri Becquerel Center  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agathe","family":"Edet\u2010Sanson","sequence":"additional","affiliation":[{"name":"QuantIF AIMS University of Rouen  Rouen France"},{"name":"Nuclear Medicine Department Henri Becquerel Center  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Vera","sequence":"additional","affiliation":[{"name":"QuantIF AIMS University of Rouen  Rouen France"},{"name":"Nuclear Medicine Department Henri Becquerel Center  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Decazes","sequence":"additional","affiliation":[{"name":"QuantIF AIMS University of Rouen  Rouen France"},{"name":"Nuclear Medicine Department Henri Becquerel Center  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Dieudonn\u00e9","sequence":"additional","affiliation":[{"name":"QuantIF AIMS University of Rouen  Rouen France"},{"name":"Nuclear Medicine Department Henri Becquerel Center  Rouen France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010022\u201005727\u20107"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLU.0000000000003169"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12020205"},{"key":"e_1_2_9_5_1","volume-title":"Medical Physics","author":"Amato E","year":"2013"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/59\/17\/4769"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/60\/20\/7861"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ab65dc"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010020\u201005013\u20104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010024\u201006618\u20109"},{"key":"e_1_2_9_11_1","unstructured":"SimpleDose.Becquerel;2023. 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