{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:15:15Z","timestamp":1784092515796,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007210","name":"Varian Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Free\u2010breathing gated cone\u2010beam computed tomography (gCBCT), which captures a specific anatomy coinciding with a preset gating window in the breathing cycle, is routinely prescribed to gating lung SBRT patients for pretreatment setup verification. However, a half\u2010fan gCBCT scan can take 2\u20138\u00a0min (for a typical gating duty cycle of 30%\u201360% and patient breathing period of 3\u20136\u00a0s) on a C\u2010arm linear accelerator because the gantry movement is interrupted and resumed by the respiratory gating signal multiple times over the scan. The long scan time increases patient on\u2010table time, leading to discomfort and a higher likelihood of patient movement. Meanwhile, extra kV projections are acquired while the gantry is accelerating for the gCBCT scan, resulting in a higher imaging dose compared to 3D CBCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the feasibility of a novel imaging paradigm named \u201cnonstop gated CBCT (ngCBCT)\u201d that improves upon current clinical gCBCT by substantially reducing the scan time and imaging dose while retaining high\u2010quality images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The ngCBCT is implemented by allowing the gantry to rotate continuously, with the kV x\u2010ray beam activated only when the breathing signal falls within the preset gating window. Raw gCBCT projections of two gating lung SBRT patients were retrospectively retrieved and intentionally sampled based on each patient's breathing cycle to emulate the ngCBCT acquisitions. The datasets include both half\u2010fan and full\u2010fan acquisitions, representing the primary clinical scan geometries. Three reconstruction algorithms\u2014Feldkamp\u2013Davis\u2013Kress (FDK), penalized likelihood iterative reconstruction (PL), and prior\u2010image\u2010based iterative reconstruction (PIBR)\u2014were applied to these ngCBCT emulations to evaluate reconstruction performances on the non\u2010uniform and under\u2010sampled projections resulting from this acquisition strategy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The FDK reconstructions of ngCBCT are degraded with streak artifacts and have insufficient quality for clinical use. While PL yields improved reconstructions over FDK, the PIBR method consistently delivers the best visual and quantitative results with the aid of patient\u2010specific prior images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed ngCBCT technique addresses the key limitations of current clinical gCBCT by substantially reducing data acquisition time and imaging dose. The ngCBCT with PIBR achieves adequate image quality and offers a promising opportunity for pretreatment setup verification in gating lung SBRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.18084","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T06:42:33Z","timestamp":1756795353000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Nonstop gated CBCT for respiratory gating lung SBRT: A feasibility study"],"prefix":"10.1002","volume":"52","author":[{"given":"Mitchell","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Berry","sequence":"additional","affiliation":[{"name":"Department of Medical Physics Memorial Sloan Kettering Cancer Center  New York New York 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