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Despite its widespread use in industrial gamma radiography, a\n                      <jats:sup>75<\/jats:sup>\n                      Se brachytherapy source has yet to be\u00a0manufactured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      A novel\n                      <jats:sup>75<\/jats:sup>\n                      Se\u2010based source design with a vanadium diselenide core, titled the SeCure source, was proposed. This study aimed to evaluate the feasibility of this source design for dosimetry and manufacturability purposes and to develop an activated prototype\u00a0source.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The source was modeled and integrated into the Monte Carlo\u2010based treatment planning system RapidBrachyMCTPS, where its TG\u201043U1 parameters, photon spectrum, and broad beam first half\u2010value layers (HVL\n                      <jats:sub>1<\/jats:sub>\n                      ) and tenth\u2010value layers (TVL\n                      <jats:sub>1<\/jats:sub>\n                      ) in lead, tungsten, and concrete were calculated. A prototype source was manufactured, and the vanadium diselenide content of the capsule was verified with neutron radiography. The source was then activated to a nominal activity of  mCi at the McMaster Nuclear Reactor. The activity was measured with two separate dose calibrators. Gamma spectroscopy was used to characterize any activated radioactive contaminants in the source, and wipe testing was performed to check for any leakage of\n                      <jats:sup>75<\/jats:sup>\n                      Se from the\u00a0encapsulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The SeCure source's TG\u201043U1 parameters were computed, showing that  times the activity of\n                      <jats:sup>75<\/jats:sup>\n                      Se is required relative to\n                      <jats:sup>192<\/jats:sup>\n                      Ir to achieve the same dose rate in water at (1 cm, 90). The mean spectral energy of the source is  keV, resulting in reduced first half\u2010value and tenth\u2010value layers relative to\n                      <jats:sup>192<\/jats:sup>\n                      Ir in attenuating materials. For example, the  was reduced from  mm to  mm in lead, from  mm to  mm in tungsten, and from  mm to  mm in concrete. The activated source achieved the desired activity, indicated as  mCi and  mCi at the end of irradiation on the two dose calibrators. All identified radionuclide contaminants decaying below  of the\n                      <jats:sup>75<\/jats:sup>\n                      Se activity after 5 days post\u2010irradiation. Wipe testing only identified radioactive contaminants present in activated titanium, with only  mCi of  detected 72 h post\u2010irradiation, indicating that the integrity of the encapsulation was\u00a0maintained.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The SeCure design possesses the dosimetric, spectral, and physical properties necessary for a feasible high dose rate brachytherapy source. Next, manufacturing of a high\u2010activity SeCure source will be\u00a0pursued.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.18088","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T06:59:51Z","timestamp":1757487591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development and characterization of a prototype selenium\u201075 high dose rate brachytherapy source"],"prefix":"10.1002","volume":"52","author":[{"given":"Jonathan","family":"Kalinowski","sequence":"first","affiliation":[{"name":"Medical Physics Unit Department of Oncology Faculty of Medicine McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Lady Davis Institute for Medical Research Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Tal","sequence":"additional","affiliation":[{"name":"Lady Davis Institute for Medical Research Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake","family":"Reid","sequence":"additional","affiliation":[{"name":"Medical Physics Unit Department of Oncology Faculty of Medicine McGill University Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Lady Davis Institute for Medical Research Jewish General Hospital Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John","family":"Munro","sequence":"additional","affiliation":[{"name":"Burnley Technology Inc. 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