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However, BNCT is limited by current dosimetry methods that are incapable of monitoring boron distribution during therapy. An imaging system capable of real\u2010time dosimetry is essential for optimizing treatment efficacy and minimizing collateral\u00a0damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to develop a high\u2010resolution real\u2010time boron dosimetry system for BNCT by employing a cadmium telluride double\u2010sided strip detector (CdTe\u2010DSD). The CdTe\u2010DSD enables precise mapping of  distribution by detecting the 478\u00a0keV prompt \u2010rays emitted during the \u00a0reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The imaging system was constructed by integrating a CdTe\u2010DSD with a 2\u2010mm diameter pinhole collimator. The CdTe\u2010DSD, comprising a 2\u2010mm\u2010thick CdTe semiconductor, has a sensitive area of 32 32\u00a0. Neutron irradiation experiments were performed at Japan Research Reactor No. 3 using various boron\u2010containing samples, including boric acid solutions, powders, and granular boron, with boron masses ranging from 0.02 to 2.00\u00a0mg. We implemented the neutron shields using a 5\u2010mm\u2010thick  plate and LiF tiles to reduce the background from scattered neutrons during the\u00a0measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The imaging system successfully detected the 478\u00a0keV \u2010ray signal with an energy resolution of 7.3\u00a0keV at 511\u00a0keV. The reconstructed two\u2010dimensional  images demonstrate the capability of the CdTe\u2010DSD to accurately map the  distribution in the samples. Notably, we evaluated the important background contributions from the scattering neutrons in the development of the CdTe\u2010DSD\u2010based imaging system. When the scattering neutrons in a neutron experiment hit the CdTe\u2010DSD, 558\u00a0keV \u2010rays of  were produced. Under three experimental conditions with different neutron shielding configurations, we found that enhanced neutron shielding considerably reduced the background contribution created by the  background signal, thereby improving the contrast\u2010to\u2010noise ratio (CNR) in the image quality assessment. Upon comparing the condition with minimal neutron shielding to that with maximal shielding, a 14\u2010fold enhancement in the CNR was\u00a0observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates that a CdTe\u2010DSD\u2010based gamma camera is a promising tool for real\u2010time boron dosimetry in BNCT. The detector's high energy resolution and excellent spatial resolution enable precise detection of 478\u00a0keV prompt \u2010rays, facilitating accurate mapping of boron distribution during neutron irradiation. These findings support the developed system's potential to enhance BNCT treatment planning and patient\u2010specific dose monitoring. Future research will optimize neutron shielding and explore advanced collimator designs to improve sensitivity in clinical\u00a0settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70062","type":"journal-article","created":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T08:30:09Z","timestamp":1759912209000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of a CdTe semiconductor\u2010based gamma camera for real\u2010time dose dosimetry in boron neutron capture therapy"],"prefix":"10.1002","volume":"52","author":[{"given":"I\u2010Huan","family":"Chiu","sequence":"first","affiliation":[{"name":"Materials Sciences Research Center Japan Atomic Energy Agency Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Osawa","sequence":"additional","affiliation":[{"name":"Materials Sciences Research Center Japan Atomic Energy Agency Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Sumita","sequence":"additional","affiliation":[{"name":"Department of Materials Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Ninomiya","sequence":"additional","affiliation":[{"name":"Natural Science Center for Basic Research and Development Hiroshima University Higashi\u2010Hiroshima Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin'ichiro","family":"Takeda","sequence":"additional","affiliation":[{"name":"Fukushima Institute for Research, Education and Innovation (F\u2010REI) Fukushima Japan"},{"name":"Kavli Institute for the Physics and Mathematics of the Universe (WPI) The University of Tokyo Kashiwa Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadayuki","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Kavli Institute for the Physics and Mathematics of the Universe (WPI) The University of Tokyo Kashiwa Chiba Japan"},{"name":"International Center for Quantum\u2010field Measurement Systems for Studies of the Universe and Particles (QUP, WPI) High Energy Accelerator Research Organization (KEK) Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2004.05.059"},{"key":"e_1_2_9_3_1","first-page":"1","article-title":"LG. 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