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However, its application to luminal tissues (e.g., digestive tract, vasculature) is significantly hindered by low image quality due to acoustic wave attenuation and inherent tissue properties.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to overcome the image quality limitation in MAT\u2010MI imaging of luminal structures by utilizing liquid metal (LM) as a novel conductive contrast agent and implementing M\u2010sequence coded excitation to enhance signal strength and acquisition efficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The LM contrast agent used was a biocompatible Ga\n                      <jats:sub>67<\/jats:sub>\n                      In\n                      <jats:sub>20.5<\/jats:sub>\n                      Sn\n                      <jats:sub>12.5<\/jats:sub>\n                      alloy (\n                      <jats:italic>\u03c3<\/jats:italic>\n                      \u00a0=\u00a03.1\u00d710\u2076 S\/m). MAT\u2010MI experiments were conducted on gel phantoms containing LM in various shapes and simulated luminal structures (PVC tubes, ex vivo mouse intestines), ex vivo mouse stomach tissues infused with LM or PBS (control), and in vivo mouse stomachs. The MAT\u2010MI system employed 0.34 T static magnetic field, a pulsed excitation coil (1\u00a0MHz center frequency), and an ultrasound transducer. We applied M\u2010sequence coded excitation (up to 31\u2010bit) and processed the signals using pulse compression followed by filtered back\u2010projection reconstruction. Safety was assessed via long\u2010term biocompatibility studies, blood elemental analysis, and histological examination (H&amp;E staining) of gastrointestinal tissues.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Integrating LM into the imaging target greatly increased the MAT\u2010MI signal intensity. In vivo imaging of mouse stomachs demonstrated an approximate 28\u00a0dB increase in image quality after LM infusion compared to pre\u2010infusion imaging. LM enabled clear visualization within fine luminal structures (down to 0.5\u00a0mm inner diameter) in phantoms and ex vivo tissues. M\u2010sequence coding further improved image clarity and reduced total imaging time by approximately 84% relative to single\u2010pulse excitation (from 6360\u00a0s to 1020\u00a0s for comparable image quality). High\u2010resolution imaging (approximately 2\u00a0mm spatial resolution) of LM distribution was achieved. The LM was safely excreted, with no significant toxicity observed in blood analysis or histology over 180 days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>LM proved to be an effective and safe contrast agent for MAT\u2010MI, significantly enhancing image quality and enabling high\u2010quality imaging of luminal tissues, including the first successful in vivo visualization of the stomach in a live animal model. Combined with M\u2010sequence coded excitation, this approach overcomes key limitations of conventional MAT\u2010MI and could broaden its diagnostic utility in cardiovascular and gastrointestinal imaging.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70249","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:05:12Z","timestamp":1767179112000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research on the method of improving magnetoacoustic tomography quality based on liquid metal"],"prefix":"10.1002","volume":"53","author":[{"given":"Junjie","family":"Lin","sequence":"first","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenshu","family":"Mai","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangxuan","family":"Chu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunqi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering Chinese Academy of Medical Sciences &amp; Peking Union Medical College, State Key Laboratory of Advanced Medical Materials and Devices, Tianjin Institutes of Health Science, Tianjin Key Laboratory of Neuromodulation and Neurorepair  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/0022\u20103735\/17\/9\/002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1137\/S0036144598333613"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1999.tb09481.x"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2002.800604"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/29\/10\/R01"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031\u20109155\/61\/18\/R249"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/ebm.2010.010236"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.7300"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.1994.6492304"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/10.650364"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","unstructured":"HeB High\u2010resolution Functional Source and Impedance Imaging. 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