{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:01:36Z","timestamp":1777906896447,"version":"3.51.4"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Ministry of Trade, Industry and Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003661","name":"Korea Institute for Advancement of Technology","doi-asserted-by":"publisher","award":["P0026103"],"award-info":[{"award-number":["P0026103"]}],"id":[{"id":"10.13039\/501100003661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ruthenium\u2010106 (Ru\u2010106) plaque brachytherapy is an established treatment modality for choroidal melanoma that delivers localized beta radiation while sparing surrounding ocular structures. It is widely used in Europe and parts of Asia, whereas COMS Iodine\u2010125 and Palladium\u2010103 plaques remain the standard in the United States. However, its concave geometry presents challenges for accurate dose verification, as conventional flat dosimeters are ill\u2010suited for use during commissioning and quality assurance (QA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to assess the feasibility and dosimetric accuracy of a plaque\u2010adaptive flexible film dosimeter (PFD) for planar and central axis (CAX) dose measurements in Ru\u2010106 plaque brachytherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The PFD consisted of an active layer of lithium salt of pentacosa\u201010,12\u2010diynoic acid (LiPCDA) enclosed between upper and lower silicone sheets. The flexible film was shaped to conform to the curvature of the Ru\u2010106 plaques and mounted within a dual\u2010layer film holder. A 3D\u2010printed QA tool was used for reproducible positioning. Dose measurements were performed at depths of 1 and 3\u00a0mm for CCA, COB, and CIB plaque types using a dual\u2010film configuration. Planar dose distributions were assessed at 33 manufacturer\u2010certified reference points at a 1\u00a0mm depth. CAX dose profiles were independently acquired using a microDiamond detector in a water phantom. All measurements were compared with manufacturer\u2010certified reference data. Calibration curves were established based on optical density and dose uncertainties were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The dose ratio between 1 and 3\u00a0mm depths measured with the PFD differed by \u20130.2% to 0.4% from the reference data across all plaque types. Planar dose measurements at 33 points yielded a mean difference of 3.0%\u00a0\u00a0\u00b1\u00a0\u00a02.0% from reference values. In the high\u2010dose central region, the mean differences for CCA, COB, and CIB were 2.1%\u00a0\u00a0\u00b1\u00a0\u00a00.8%, 2.1%\u00a0\u00a0\u00b1\u00a0\u00a00.8%, and 2.2%\u00a0\u00a0\u00b1\u00a0\u00a00.7%, respectively. CAX dose profiles measured with a microDiamond detector differed by 0.89%\u00a0\u00a0\u00b1\u00a0\u00a00.58%. Total dose uncertainty ranged from 4.43% at 0.3\u00a0Gy to 4.19% at 2.4\u00a0Gy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The PFD enabled accurate and high\u2010resolution dose measurements on the curved surfaces of Ru\u2010106 plaques. Both planar and CAX measurements demonstrated strong agreement with manufacturer\u2010certified reference data across all plaque types. This system offers a practical and reproducible solution for commissioning and QA in Ru\u2010106 plaque brachytherapy, supporting its clinical integration for choroidal melanoma treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70286","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:56:46Z","timestamp":1773201406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plaque\u2010adaptive flexible film dosimetry system for Ru\u2010106 plaque brachytherapy commissioning and quality assurance"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1914-8163","authenticated-orcid":false,"given":"Jin Dong","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5616-8887","authenticated-orcid":false,"given":"Hojae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5819-9783","authenticated-orcid":false,"given":"Dong Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Radiation Oncology Yonsei University College of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1118-8200","authenticated-orcid":false,"given":"Heerim","family":"Nam","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-6471","authenticated-orcid":false,"given":"Jin Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Department of Radiation Oncology Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Medical Physics and Biomedical Engineering Lab (MPBEL) Yonsei University College of Medicine  Seoul Republic of Korea"},{"name":"Oncosoft  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-5969","authenticated-orcid":false,"given":"Jung\u2010in","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Radiation Oncology Seoul National University College of Medicine  Seoul Republic of Korea"},{"name":"Institute of Radiation Medicine Seoul National University Medical Research Center  Seoul Republic of Korea"},{"name":"Biomedical Research Institute Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.84.9.1068"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.02.051"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/CANCERS16193386"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_1291_23"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-0490-3_19"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-17879-6_12"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1051\/BIOCONF\/20191407005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/RPD\/NCM486"},{"key":"e_1_2_8_10_1","first-page":"27","volume-title":"Dev. 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