{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T17:06:54Z","timestamp":1789492014991,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P20GM135009"],"award-info":[{"award-number":["P20GM135009"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005625","name":"RSNA Research and Education Foundation","doi-asserted-by":"publisher","award":["RSCH2302"],"award-info":[{"award-number":["RSCH2302"]}],"id":[{"id":"10.13039\/100005625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Contrast enhancement is the most sensitive indicator for detecting breast malignancies. Computed tomography (CT) has had a limited role for the locoregional staging of breast tumors due to low soft tissue contrast.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To evaluate and optimize the performance of clinical photon\u2010counting computed tomography (PCCT) for breast cancer imaging using a contrast\u2010enhanced mammography (CEM) phantom and to compare its imaging performance with dual\u2010source dual\u2010energy CT (DS\u2010DECT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A CEM phantom containing simulated breast lesions was positioned on an anthropomorphic thoracic phantom and scanned using a clinical PCCT system at 120\u00a0kV in multi\u2010energy mode and a DS\u2010DECT system with two kV pairs of 70\/Sn150 kV and 90\/Sn150 kV. PCCT scanner variables included scan mode [standard resolution (SR) and ultra\u2010high resolution (UHR)], field of view (FOV) size (large and small), matrix size (512 and 1024), and type of image used for analysis [low\u2010energy threshold images, virtual monoenergetic images (VMIs) at 50, 60, and 70\u00a0keV, and iodine maps]. Quantitative analysis was performed using circular regions of interest (ROIs) placed on iodine\u2010containing lesions and background within the phantom. For each ROI, mean CT numbers or iodine concentrations and standard deviations were measured across the central five slices and three independent scans. Contrast\u2010to\u2010noise ratio (CNR) and circularity were evaluated across all PCCT configurations and image types and compared with those obtained from DS\u2010DECT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among all PCCT configurations, the UHR mode with a small FOV and either a 512\u00a0or 1024\u00a0matrix at 50\u00a0keV VMI achieved the highest combined CNR across all iodine concentrations. Additionally, the UHR mode with a 512\u00a0matrix and either small or large FOV yielded the highest combined circularity values. The optimal PCCT configuration achieved higher CNR, and higher or comparable circularity compared with 50\u00a0keV VMIs derived from DECT scans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This phantom study demonstrated that optimal spectral performance for potential breast cancer imaging with PCCT is achieved using UHR mode, low\u2010keV VMIs, a regular matrix size, and dedicated reconstruction FOVs, outperforming DECT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70472","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T04:07:31Z","timestamp":1778645251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phantom evaluation of spectral performance in photon\u2010counting CT for breast cancer imaging"],"prefix":"10.1002","volume":"53","author":[{"given":"Liqiang","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lakshmi","family":"Ananthakrishnan","sequence":"additional","affiliation":[{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Soesbe","sequence":"additional","affiliation":[{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Seiler","sequence":"additional","affiliation":[{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afrouz","family":"Ataei","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Nuclear Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Electrical and Computer Engineering University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Li","sequence":"additional","affiliation":[{"name":"School of Electrical and Computer Engineering University of Oklahoma  Norman Oklahoma USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard W.","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Radiology UT Southwestern Medical Center  Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2013.04.012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190887"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10070479"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2024.02.021"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0035"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12111699"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142631"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2019.02.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-020-06878-7"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2020.12.027"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2017.08.001"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9121"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2022.11.003"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-019-00897-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.18.20953"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2019180115"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","unstructured":"RenL SoesbeT LewisM et\u00a0al.Evaluation of spectral performance in photon\u2010counting CT for breast cancer imaging: a feasibility phantom study. vol13405.SPIE Medical Imaging. 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