{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T20:32:01Z","timestamp":1786393921715,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radiance is a Monte Carlo\u2212based treatment planning software integrated into the Intrabeam system for 50\u2010kVp X\u2010rays intraoperative radiotherapy (IORT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This study evaluates\n                      <jats:italic>Radiance<\/jats:italic>\n                      accuracy in calculating absorbed dose in IORT of the breast including the effect of tissue heterogeneities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dose distributions from IORT were calculated in 88 virtual phantoms of different tissue\u2010equivalent materials. Dose was calculated independently using the penEasy code for the PENELOPE Monte Carlo engine and compared to Radiance. Depth dose curves (DDCs) were compared through gamma analysis using 5%\/0.5\u00a0mm and 3%\/0.5\u00a0mm criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      When comparing\n                      <jats:italic>Radiance<\/jats:italic>\n                      vs penEasy all passing rates were above 95%. Notable differences from dose to water emerged for some tissues: cortical bone absorbed about four times more than water, while adipose tissue received about 45% less. These variations were affected by atomic number more than density.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Radiance<\/jats:italic>\n                      results show strong agreement with penEasy simulations. Furthermore, it was observed that IORT absorbed doses can fluctuate by\u00a0\u00b1\u00a050% due to heterogeneities surrounding the applicator. This highlights that the prescribed dose and the absorbed dose in the applicator surface do not necessarily coincide in non\u2010water tissues, emphasizing the critical need to account for specific tissue characteristics during treatment planning.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70527","type":"journal-article","created":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T06:25:21Z","timestamp":1782627921000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Monte Carlo assessment of a treatment planning system for intraoperative radiotherapy in the presence of tissue heterogeneities"],"prefix":"10.1002","volume":"53","author":[{"given":"Aurora","family":"Corso","sequence":"first","affiliation":[{"name":"University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. Javier","family":"Jimenez\u2010Albericio","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario \"Lozano Blesa\" de Zaragoza Zaragoza Spain"},{"name":"Universidad de Zaragoza  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Avanzo","sequence":"additional","affiliation":[{"name":"Centro di Riferimento Oncologico di Aviano (CRO) IRCCS  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Ortega\u2010Pardina","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario \"Lozano Blesa\" de Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Cirio","sequence":"additional","affiliation":[{"name":"University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vera\u2010Tena","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario \"Lozano Blesa\" de Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Gonzalez\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario \"Lozano Blesa\" de Zaragoza Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Garcia\u2010Romero","sequence":"additional","affiliation":[{"name":"Hospital Clinico Universitario \"Lozano Blesa\" de Zaragoza Zaragoza Spain"},{"name":"Universidad de Zaragoza  Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2023.11.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/acm2.14272"},{"key":"e_1_2_10_4_1","unstructured":"Carl Zeiss Meditec AG.INTRABEAM Technical Specifications 2015."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60837-9"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2836"},{"issue":"2","key":"e_1_2_10_7_1","first-page":"196","article-title":"RADIANCE\u2014a planning software for intra\u2010operative radiation therapy","volume":"4","author":"Valdivieso\u2010Casique MF","year":"2015","journal-title":"Translational Cancer Res"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143532"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3700175"},{"key":"e_1_2_10_10_1","first-page":"271","article-title":"The significance of the R\u00d6ntgen","volume":"2","author":"Mayneord W","year":"1937","journal-title":"Unio Internationalis Contra Cancrum"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-19-218-52"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ab03e7"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.15291"},{"key":"e_1_2_10_14_1","unstructured":"Nuclear Energy Agency.PENELOPE 2018: A Code System for Monte Carlo Simulation of Electron and Photon Transport. 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