{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:19:35Z","timestamp":1788272375468,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007368","name":"Fondazione Pisa","doi-asserted-by":"publisher","award":["Prog.N.134\/2021"],"award-info":[{"award-number":["Prog.N.134\/2021"]}],"id":[{"id":"10.13039\/100007368","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The clinical translation of Minibeam RT (MBRT) has recently started thanks to the first human treatments recently performed. However, despite experimental evidence, the impact of the dose distribution parameters involved on the magnitude of the effect itself and the underlying radiobiological mechanisms are still only partially understood. To address this issue, systematic investigations are needed through the implementation of advanced quantitative experiments with a multidisciplinary approach, which is the one proposed in the framework of the INFN funded MIRO (MInibeam RadiOtherapy) project.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this work is to report on the on\u2010going main activities recently carried out in the framework of the project, showing some of the main results achieved during the first 2\u00a0years of the project, in terms of: (i) facilities development and characterization; (ii) new dosimetric approaches; (iii) biological investigation of the effect; and (iv) development of the first tools for dose planning. The multidisciplinary approach adopted by this national Collaboration to tackle the main challenges of minibeam radiotherapy for a reliable and solid clinical translation is discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The facilities involved in the project are: (i) two facilities dedicated to low (up to 9\u00a0MeV) and medium (up to 18\u00a0MeV) energy electron minibeam studies, one of them also equipped with an electron FLASH LINAC to study possible synergistic effects with UHDR beams; (ii) one facility dedicated to proton minibeam studies, with energies from 70 to 140\u00a0MeV. Novel dosimetric approaches, are presented, mainly based on scintillators, silicon and silicon carbide detectors. Novel techniques for the analysis of biological samples are described, leveraging both integrated averaged data and spatially resolved analysis. Furthermore, a framework for biological modeling using a multiscale approach is presented. A dedicated dose\u2010planning tool is currently under development to compare \u201cvirtual\u201d minibeam plans with conventional ones and, consequently, to quantitatively investigate the potential for clinical translation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All the facilities were dosimetrically characterized, demonstrating the capability of producing controlled and reproducible electron and proton minibeams. These beams exhibited diverse physical parameters, including peak\u2010to\u2010valley ratios between 3 and 30 at the entrance and center\u2010to\u2010center distances between 2 and 3\u00a0mm. The developed detectors, specifically scintillators and silicon detectors, successfully measured the minibeam patterns with sub\u2010millimeter resolution, while large\u2010area silicon carbide detectors were used for average dose measurements. First in\u2010vitro biological investigations performed with low energy minibeams clearly showed an enhanced survival fraction in the 16HBE healthy lung cells, while maintaining iso\u2010effective cell killing in A549 cancer cells. Furthermore, a synergy was observed when combining UHDR electron beams with minibeams.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The multidisciplinary approach was consolidated during these first 2\u00a0years of the MIRO project, as demonstrated by the results obtained both in terms of dosimetric characterization and biological investigations. The dedicated framework for modelling is being optimized to support the biological findings, allowing for a better interpretation of the results. The tool for dose planning, still under development, will allow the investigation of peculiar configurations to explore new frontiers in the perspective of future human trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70537","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T03:44:33Z","timestamp":1785815073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A multidisciplinary experimental and methodological investigation of electron and proton minibeams in the framework of the INFN MIRO project"],"prefix":"10.1002","volume":"53","author":[{"given":"Francesco","family":"Romano","sequence":"first","affiliation":[{"name":"Catania Division National Institute of Nuclear Physics (INFN)  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Cella","family":"Zanacchi","sequence":"additional","affiliation":[{"name":"Department of Physics \u201cE. 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