{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:45:23Z","timestamp":1792071923977,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although spatially\u2010fractionated radiation therapy (SFRT) has been receiving increasing clinical interest, its complete and optimized clinical transfer requires several technological and radiobiological issues to be addressed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The aim of this work is to setup and dosimetrically characterize an experimental platform generating planar megavoltage photon minibeams to exploit quantitative radiobiological SFRT experiments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Minibeam patterns were generated on a Varian TrueBeam\u2122 linear accelerator equipped with a high definition (HD) MLC, which consists of 60 tungsten leaf pairs, whom the 32 inner ones project a thickness of 2.5\u00a0mm at the isocenter plane (i.e., 100\u00a0cm distance from the radiation source) and the 28 outers of 5\u00a0mm. Each pattern was obtained alternating opening one leaf after closing one, two, or three of the smallest MLC leaves. Measurements were performed with a PTW microdiamond detector in edge\u2010on orientation in a water phantom over depths from 1 to 30\u00a0cm, varying the beam energy and the source to surface distance (SSD) in different sessions. A Python\u2010based in\u2010house automated fitting procedure was used to obtain from the measured profiles all the minibeam parameters: peak widths (PWs), distance between consecutive peaks (CTCs), peak to valley dose ratios (PVDRs) and depth doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The best performances were obtained at SSD\u00a0=\u00a070\u00a0cm and 6 MV, where PWs and PVDRs respectively range from 1.2 to 2.4\u00a0mm and from 2 to 7. For all patterns the average dose varies in depth analogously to the reference field, PVDRs show an almost steady decrease except at shallower depths, while PWs and CTCs widen linearly with the depths. Moreover, their variation over different sessions was within the estimated uncertainty of the single measurement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We are claiming that a Varian TrueBeam\u2122 equipped with an HD\u2010MLC represents a practical, stable, reproducible and accessible platform that might be suitable for radiobiological studies on SFRT and for the investigation of the relative underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70597","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T06:58:55Z","timestamp":1788505135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Megavoltage photon minibeam production through the embedded multi\u2010leaf collimator of a clinical linac: A dosimetric characterization"],"prefix":"10.1002","volume":"53","author":[{"given":"Stefania","family":"Linsalata","sequence":"first","affiliation":[{"name":"UO Fisica Sanitaria Azienda Ospedaliero\u2010Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jake Harold","family":"Pensavalle","sequence":"additional","affiliation":[{"name":"S.I.T. \u2010 Sordina IORT Technologies S.p.A. Aprilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiola","family":"Paiar","sequence":"additional","affiliation":[{"name":"Department of Translational Research and New Technologies in Medicine and Surgery University of Pisa Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Romano","sequence":"additional","affiliation":[{"name":"Sezione di Catania Istituto Nazionale di Fisica Nucleare (INFN) Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Claudio","family":"Traino","sequence":"additional","affiliation":[{"name":"UO Fisica Sanitaria Azienda Ospedaliero\u2010Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Di","family":"Martino","sequence":"additional","affiliation":[{"name":"UO Fisica Sanitaria Azienda Ospedaliero\u2010Universitaria Pisana Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ad4192"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2019.10.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596771"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","unstructured":"LaissueJA BlattmannH Di MichielM et\u00a0al.The weanling piglet cerebellum: a surrogate for tolerance to MRT (microbeam radiation therapy) in pediatric neuro\u2010oncology. 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