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Clinical PET\/CT scanners are optimized for whole\u2010body diagnostic imaging instead of real\u2010time guidance of interventional procedures or point\u2010of\u2010care (PoC) imaging applications. With rapid advances in novel radio\u2010theranostics, there is growing interest in versatile, accessible molecular imaging tools.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study evaluates the feasibility of a compact PET device integrated with a clinical ultrasound (US) system to enhance the utility of molecular imaging in PoC settings. Key features being evaluated include: (1) image quality from a compact system with limited angle tomography; (2) interactive scanning to provide visual feedback; and (3) near real\u2010time PET image reconstruction as data is being acquired.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The prototype PoC\u2010PET system features a robotic arm (Kuka KR 10 R1100 sixx), a rotation stage, and eight time\u2010of\u2010flight (TOF) PET detector modules mounted on a trolley. The detectors comprise Lutetium Oxy\u2010orthosilicate (LSO) arrays, silicon photomultiplier (SiPM) arrays, and front\u2010end electronics. An optional US transducer is integrated between two PET detectors, forming a hybrid PET\/US probe. The system acquires data in list\u2010mode and reconstructs PET images using a GPU\u2010accelerated list\u2010mode maximum\u2010likelihood expectation\u2010maximization (MLEM) algorithm incorporating time\u2010of\u2010flight (TOF) information. Detector characterization and calibration were performed using a planar source containing\n                      <jats:sup>64<\/jats:sup>\n                      Cu solution. A tumor phantom containing spherical lesions of different diameters (ranging from 3.3\u00a0mm to 11.4\u00a0mm) was filled with\n                      <jats:sup>18<\/jats:sup>\n                      FDG solution with a tumor\u2010to\u2010background activity concentration ratio of 20:1. Images from the PoC\u2010PET prototype are compared to reference images from a clinical PET\/CT scanner (Siemens Biograph Vision). Additionally, an ultrasound\u2010compatible silicone phantom containing\n                      <jats:sup>64<\/jats:sup>\n                      Cu solution was imaged by the PoC\u2010PET device and a clinical ultrasound scanner to compare the hybrid PET\/US images and conventional PET\/CT images. Lastly, Monte Carlo (MC) simulations were conducted to evaluate the feasibility of a scaled\u2010up portable PET device for imaging organs in humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The TOF\u2010PET detectors in the system have an energy resolution of 10.4\u00a0\u00b1\u00a00.4% full\u2010width\u2010at\u2010half\u2010maximum (FWHM) for 511\u00a0keV gamma\u2010rays and a coincidence resolving time (CRT) of \u223c267\u00a0\u00b1\u00a012\u00a0ps FWHM. Initial imaging results indicate that the compact PoC\u2010PET prototype can produce PET images with a resolution that closely approximates clinical PET\/CT resolution after data were acquired from 3 to 4 angles. The integrated PET\/US images provide both molecular and structural visualization, matching the fidelity of conventional PET\/CT systems. MC simulations show reconstructed PET images with insignificant artifacts for head\u2010and\u2010neck and torso imaging of humans using the scaled\u2010up PoC\u2010PET scanner.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A hybrid PET\/US device for molecular imaging at PoC settings is feasible. Robotic\u2010assisted scanning combined with TOF\u2010PET detectors and list\u2010mode image reconstruction enables high\u2010quality imaging comparable to traditional PET\/CT systems for any organ\u2010of\u2010interest. Real\u2010time image reconstruction and automated fusion will support multi\u2010modal interactive molecular imaging with visual feedback in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70610","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T09:40:37Z","timestamp":1786700437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility of a portable PET system for interactive point\u2010of\u2010care (PoC) PET and ultrasound imaging"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7058-6607","authenticated-orcid":false,"given":"Samarth","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Imaging Science Doctoral Program Washington University in St. Louis  St. Louis Missouri 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