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With the availability of breast cancer specific PET radiotracers, such a scanner has the potential to improve treatment planning in breast cancer. We recently developed a BPET\u2013DBT scanner utilizing an integrated gantry design to generate intrinsically co\u2010registered BPET\u2013DBT images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This paper presents the scanner design, characterizes its imaging performance, and reports on our initial human imaging experience to demonstrate scanner's clinical readiness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The PET component is comprised of two detector heads, providing a 20 \u00d7 10 \u00d7 10 cm\n                      <jats:sup>3<\/jats:sup>\n                      scanner field\u2010of\u2010view. The detector provides time\u2010of\u2010flight (TOF) measurement and is comprised of 32\u00d732 LYSO arrays of 1.5 \u00d7 1.5 \u00d7 15\u00a0mm\n                      <jats:sup>3<\/jats:sup>\n                      crystals coupled to multi\u2010anode PMTs. Custom waveform\u2010sampling electronics ensures high spatial and timing resolution with minimal deadtime. The DBT component is a state\u2010of\u2010the\u2010art system which employs 2D x\u2010ray tube and detector motion for improved contrast and resolution. Phantoms appropriate for breast imaging were imaged to assess spatial resolution, image quantitation, count\u2010rate capability, and co\u2010registration accuracy. First human imaging was performed in volunteers with estrogen\u2010receptor\u2010positive (ER+) breast cancer. A five\u2010minute BPET\u2013DBT scan using\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010fluoroestradiol was acquired and compared with a whole\u2010body PET scan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>System timing resolution of 425\u00a0ps and energy resolution of 16% were measured. Spatial resolution measurements showed an in\u2010plane (parallel to the detector) resolution of 2\u00a0mm and demonstrates the ability to resolve 1.6\u00a0mm rods in the micro\u2010deluxe hot rod phantom. TOF reconstruction combined with image\u2010based resolution modeling mitigates artifacts typical in scanners with incomplete angular coverage and enables good out\u2010of\u2010plane (orthogonal to detector) discrimination of the 2.4\u00a0mm rods. Count\u2010rate measurements confirm low scanner dead\u2010time, with sufficient count\u2010rate capability for clinical use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We successfully constructed and tested a BPET scanner and integrated it with DBT. BPET scanner performance was characterized, and imaging capabilities relevant for clinical imaging have been highlighted. Images from a patient with ER+ breast cancer show clear tumor delineation and visualization of heterogeneous uptake, as also seen with WB\u2010PET. This approach offers a promising strategy for improved treatment planning and outcomes in breast cancer care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70651","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:59:36Z","timestamp":1789451976000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Design and imaging performance of BPET\u2013DBT \u2013 a dedicated scanner for breast imaging"],"prefix":"10.1002","volume":"53","author":[{"given":"Srilalan","family":"Krishnamoorthy","sequence":"first","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Ashmanskas","sequence":"additional","affiliation":[{"name":"Department of Physics and Astronomy University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Werner","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Matej","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juhi","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor L.","family":"Vent","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe J.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D. 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