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As with any novel radiotherapy technique, successful translation into routine clinical practice requires robust evidence of efficacy, safety, and technical feasibility. This review presents a coordinated roadmap for the development and future implementation of PMBT, identifying the key challenges that must be addressed to enable safe and effective clinical implementation. This review highlights the interconnected nature of PMBT research and proposes the priority areas for future investigation, and the steps necessary to guide PMBT from experimental concept, towards clinical implementation. As most of the steps are relevant to all particle types, PMBT will be referred to in general, where specific particle types will be discussed where appropriate.<\/jats:p>","DOI":"10.1002\/mp.70660","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:56:22Z","timestamp":1789451782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Roadmap for the implementation of particle minibeam therapy"],"prefix":"10.1002","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5529-9802","authenticated-orcid":false,"given":"Reem","family":"Ahmad","sequence":"first","affiliation":[{"name":"Radiotherapy and Radiation Dosimetry Group National Physical Laboratory  Teddington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oxana","family":"Actis","sequence":"additional","affiliation":[{"name":"Center for Proton Therapy Paul Scherrer Institute (PSI)  Villigen 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