{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:57:13Z","timestamp":1792083433056,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DC022228"],"award-info":[{"award-number":["R01DC022228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["aapm.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Medical Physics"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Metallic inner\u2010 and middle\u2010ear implants with submillimeter structures requiring ultra\u2010high resolution (UHR) imaging invariably result in metal artifacts at CT, which can obscure adjacent microstructures and subtle pathologic findings. Current metal artifact reduction techniques can be less effective for small metal objects or metal in heterogeneous background anatomy, and can sometimes introduce new artifacts or noise.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To develop and evaluate an image\u2010domain convolutional neural network to reduce metal artifacts near inner\u2010 and middle\u2010ear implants in UHR photon\u2010counting\u2010detector (PCD)\u2010CT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>For network training, three stapes prosthesis models containing titanium and platinum were randomly oriented within a head\u2010sized phantom and imaged on a PCD\u2010CT with a UHR protocol. Metal and metal+artifact images were isolated by subtraction of the phantom background followed by CT number thresholding. Isolated artifact signal was enhanced via multiplication with a randomized factor ranging from one to a pre\u2010determined artifact amplification scalar hyperparameter. Paired training inputs (with artifacts) and labels (without artifacts) were created by adding metal\u2010free patient temporal bone images with metal+artifact and metal images, respectively. Combinations of 9 patient CT volumes and 24 metal CT volumes were used to create 216 CT volumes for training and validation with an 80%\/20% training\/validation split. The network was retrained with different amplification scalars (5, 10, 20, 30, 40) and with either mean\u2010squared\u2010error or mean\u2010absolute\u2010error loss functions to determine the optimal combination of these hyperparameters. The network was tested on 7 CT volumes from patients with three different implant types: stapes prostheses, cochlear implants, and a transverse sinus stent. Network performance was quantified through the artifact index, noise magnitude, CT number preservation of metal and bone, and dimensions of metal measured as the full\u2010width at half\u2010maximum of CT number line profiles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Networks trained with mean\u2010squared\u2010error demonstrated a trade\u2010off between metal artifact reduction and preservation of bone CT number as the artifact amplification scalar changed. The trade\u2010off was not observed when mean\u2010absolute error was used. Using the network with hyperparameters that best preserved bone and reduced artifacts simultaneously (mean\u2010absolute\u2010error, amplification scalar 20), the artifact index was improved by 83.2% (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001) across all implant types, and image noise was reduced by 46.8% (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). Artifact reduction was significantly better for cases with stapes prostheses than the other implant types (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.004), although artifact index was still greatly improved for all implant types (91.1% for the stapes prostheses, 81.3% for the CI, and 72.9% for the transverse sinus stent). Metal implant dimensions were not significantly different between the network input and output images (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.67).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An image\u2010domain convolutional neural network with task\u2010specific hyperparameters reduced artifact severity and image noise in UHR PCD\u2010CT of different inner\u2010 and middle\u2010ear implants without loss of fine image detail.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mp.70711","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T04:30:49Z","timestamp":1792038649000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Convolutional neural network metal artifact reduction in ultra\u2010high resolution photon counting detector CT of middle\u2010 and inner\u2010ear implants"],"prefix":"10.1002","volume":"53","author":[{"given":"Kevin J.","family":"Treb","sequence":"first","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Sadeghian","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"},{"name":"Mayo Clinic Graduate School of Biomedical Sciences Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"},{"name":"Department of Radiation Oncology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Farnsworth","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John I.","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Benson","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Favazza","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Department of Radiology Mayo Clinic  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