{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:41:40Z","timestamp":1759178500866},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2002,9,12]],"date-time":"2002-09-12T00:00:00Z","timestamp":1031788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>US and European practices differ with respect to treating hepatoblastoma (HB). Should chemotherapy be given prior to resection in <jats:italic>all<\/jats:italic> cases, and even without biopsy confirmation (SIOPEL)?<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure and Results<\/jats:title><jats:p>US data indicate that 40% of HBs are primarily resectable with no operative mortality and that those with pure fetal histology and low mitotic rate do not require toxic chemotherapy. They also suggest that those with a significant fraction of small undifferentiated cells do not respond to otherwise effective chemotherapy. Both US and European studies report a significant error rate in the clinical and imaging diagnosis of HB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although only 6.5% of confirmed HBs fall into categories that would be managed differently by US standards, there is no justification for denying those patients a more appropriate treatment nor should the 6\u201310% of cases that are misdiagnosed as HB be treated incorrectly. 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