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These cells either occur as single, immunohistochemically detectable elements, or form incomplete and complete duct\u2010like profiles in continuation with embryonal, fetal or macrotrabecular hepatoblastoma components. As a working formulation it is proposed to employ the term, hepatoblastoma with cholangioblastic features (or \u2018cholangioblastic\u2019 hepatoblastoma), to denote such lesions. This bimodal differentiation presents itself in other rare tumors in the form of complex arrays of duct\u2010like cells encircling nests of neoplastic hepatocyte lineage cells, in some way mimicking a ductal plate. A possible pathogenetic pathway is suggested, i.e., uni\u2010 or bipotential neoplastic progenitors switch into either of the two lineages. Med Pediatr Oncol 2002;39:487\u2013491. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.10173","type":"journal-article","created":{"date-parts":[[2002,10,8]],"date-time":"2002-10-08T22:49:09Z","timestamp":1034117349000},"page":"487-491","source":"Crossref","is-referenced-by-count":57,"title":["Hepatoblastoma with cholangioblastic features (\u2018cholangioblastic hepatoblastoma\u2019) and other liver tumors with bimodal differentiation in young patients"],"prefix":"10.1002","volume":"39","author":[{"given":"Arthur","family":"Zimmermann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,9,12]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1967)20:3<396::AID-CNCR2820200308>3.0.CO;2-O"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198210000-00002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198212000-00001"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(83)80005-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890901)64:5<1082::AID-CNCR2820640520>3.0.CO;2-G"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860601)57:11<2168::AID-CNCR2820571115>3.0.CO;2-M"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1007317"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197003)25:3<551::AID-CNCR2820250309>3.0.CO;2-5"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841101)54:9<2035::AID-CNCR2820540943>3.0.CO;2-Q"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199009000-00006"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930715)72:2<361::AID-CNCR2820720209>3.0.CO;2-3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90231-S"},{"key":"e_1_2_1_14_2","first-page":"106","article-title":"Differentiation of hepatocytes and cholangiocytes in the embryonal and postnatal periods of rat ontogenesis (in Russian)","volume":"82","author":"Verin VK","year":"1982","journal-title":"Arkh Anat Gistol Embriol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(01)00011-3"},{"key":"e_1_2_1_16_2","first-page":"379","article-title":"Infantile mesenchymal hamartoma of the liver. 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