{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T06:56:27Z","timestamp":1761893787541,"version":"3.37.3"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2003,1,27]],"date-time":"2003-01-27T00:00:00Z","timestamp":1043625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Interdisciplinary Steering Committee of the Finsen Centre"},{"DOI":"10.13039\/100009512","name":"Agnes and Poul Friis Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009512","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jens Christensen and Wife Korna Christensen Foundation"},{"name":"Ib Henriksen Foundation"},{"DOI":"10.13039\/100008363","name":"Danish Cancer Society","doi-asserted-by":"crossref","award":["92-016"],"award-info":[{"award-number":["92-016"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"crossref"}]},{"name":"F\u00d8TEK"},{"DOI":"10.13039\/501100008442","name":"Danish Dairy Research Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008442","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2003,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sex hormone deficiency or growth hormone deficiency may cause excess fatness after treatment for childhood malignant lymphoma. Previous studies of the body composition after treatment for childhood cancer included few survivors of malignant lymphoma who were not analysed separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>We measured the whole\u2010body percent fat by dual energy X\u2010ray absorptiometry (DXA) and the body\u2010mass index (weight\/height<jats:sup>2<\/jats:sup> (kg\/m<jats:sup>2<\/jats:sup>), BMI) in survivors of childhood Hodgkin disease (n\u2009=\u200923) or non\u2010Hodgkin lymphoma (n\u2009=\u200921) a median of 11 years after diagnosis (range 2\u201325). Results were compared with local data on 463 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adjusted for sex and age, the mean BMI did not differ from that of local controls, but the mean whole\u2010body percent fat was significantly increased (0.8 SD above predicted, <jats:italic>P<\/jats:italic>\u2009=\u20090.0001). Sixteen of 44 participants had a percent fat above the 90 percentile of the reference values, which indicates excess fatness. Adjusted for sex and age, percent fat was significantly higher in persons treated for non\u2010Hodgkin lymphoma. Controlled for this, the whole\u2010body percent fat was not significantly related to sex, age at diagnosis, length of follow\u2010up, sex hormone therapy at follow\u2010up or the cumulative dose of corticosteroids or doxorubicin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Eleven years after diagnosis of childhood Hodgkin disease or non\u2010Hodgkin lymphoma, the whole\u2010body percent fat was increased whereas the BMI was like that of the controls. This indicates a reduced lean body mass. Med Pediatr Oncol 2003;40:239\u2013243. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpo.10260","type":"journal-article","created":{"date-parts":[[2003,1,29]],"date-time":"2003-01-29T15:38:47Z","timestamp":1043854727000},"page":"239-243","source":"Crossref","is-referenced-by-count":21,"title":["Degree of fatness after treatment of malignant lymphoma in childhood"],"prefix":"10.1002","volume":"40","author":[{"given":"Karsten","family":"Nysom","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Holm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim Fleischer","family":"Michaelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f8rn","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"M\u00f8lgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,2,10]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13636.x"},{"key":"e_1_2_1_3_2","first-page":"83","volume-title":"Anthropometric assessment of nutritional status","author":"Cole TJ","year":"1991"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.1993.1014"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114770"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199211053271904"},{"key":"e_1_2_1_7_2","first-page":"1","article-title":"Height, weight and mortality. The Norwegian experience","volume":"679","author":"Waaler HT","year":"1984","journal-title":"Acta Med Scand Suppl"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199801013380101"},{"key":"e_1_2_1_9_2","first-page":"411","article-title":"Secular trends in body mass index among Danish young men","volume":"14","author":"S\u00f8rensen TIA","year":"1990","journal-title":"Int J Obes"},{"key":"e_1_2_1_10_2","first-page":"216","article-title":"Evaluation of dual energy X\u2010ray absorptiometry as a method of measurement of body fat","volume":"47","author":"Pritchard JE","year":"1993","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(98)70433-0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301143280211"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.8.2423"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/ajcn\/55.5.918","article-title":"Body composition in growth hormone\u2010deficient adults","volume":"55","author":"Binnerts A","year":"1992","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.2.304"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1350135"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.12.4358"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.8.2670"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.7.1062"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.4.298"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00622.x"},{"key":"e_1_2_1_22_2","first-page":"4591","article-title":"Degree of fatness after treatment for acute lymphoblastic leukaemia in childhood [published erratum appears in J Clin Endocrinol Metab. 2001 Apr;86(4):1758]","volume":"84","author":"Nysom K","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198624000-00005"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1992.10.1.128"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.2.147"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199507000-00015"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70258-X"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.2.161"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1211965"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.8.3051"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199804)30:4<240::AID-MPO6>3.0.CO;2-G"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.1245"},{"key":"e_1_2_1_33_2","first-page":"13","article-title":"Body Mass Index variations: Centiles from birth to 87 years","volume":"45","author":"Rolland\u2010Cachera MF","year":"1991","journal-title":"Eur J Clin Nutr"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"e_1_2_1_35_2","unstructured":"WHO.2000.Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. Geneva. WHO Technical Report Series. no. 894."},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.1.9"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8043(97)00076-6"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810223391703"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780111005"},{"volume-title":"SAS\/STAT(R) Users Guide. Version 6","year":"1989","author":"SAS Institute Inc","key":"e_1_2_1_40_2"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13806.x"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801515"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199805000-00008"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199608)27:2<92::AID-MPO5>3.0.CO;2-O"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199810000-00015"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90018-7"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1630055"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.7.1208"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.10260","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.10260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T15:14:40Z","timestamp":1700234080000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.10260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,10]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,4]]}},"alternative-id":["10.1002\/mpo.10260"],"URL":"https:\/\/doi.org\/10.1002\/mpo.10260","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"type":"print","value":"0098-1532"},{"type":"electronic","value":"1096-911X"}],"subject":[],"published":{"date-parts":[[2003,2,10]]}}}