{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:58:45Z","timestamp":1760547525353},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2003,5,16]],"date-time":"2003-05-16T00:00:00Z","timestamp":1053043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"IBISCUS"},{"name":"Associazione Italiana Ricerca sul Cancro 1997"},{"name":"Regione Sicilia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We examined two proteins, prolylhydroxylase (hPH) and procollagen type III (PIIIP), as possible non\u2010invasive HCV\u2010related markers of liver disease. The purpose of this study was to assess whether the measurement of these proteins could serve to monitor HCV related liver damage in acute lymphoblastic leukaemia (ALL) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>A total of 34 ALL patients, 24 HCV\u2010seropositive and 10 HCV\u2010seronegative, who had had increased transaminase values (ALT) for almost 6 months were studied. Serum hPH concentrations were determined by an immuno\u2010enzymatic assay kit. PIIIP was assayed by the radioimmunoassay method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both hPH and PIIIP were increased in ALL patients with chronic hepatitis C. Serum hPH levels were significantly elevated in those with chronic hepatitis C with either normal or high transaminases when compared to those who never were HCV seropositive. The sensitivity and specificity of these protein measurements to evaluate hepatic fibrosis were not supported by histologic confirmation because only 6 out of 12 patients with chronic hepatitis had a liver biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study suggests that PIIIP and hPH values are significantly higher in ALL patients with chronic HCV with either normal or high transaminases. This might suggest that the liver damage is more marked in patients with chronic hepatitis and that the liver damage is related to the HCV rather than chemotherapy. Future studies correlating histologic findings with the serum biochemical markers are required to establish the sensitivity and specificity of hPH and PIIIP in predicting hepatic fibrosis and to confirm this association. Med Pediatr Oncol 2003;41:17\u201320. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpo.10309","type":"journal-article","created":{"date-parts":[[2003,5,19]],"date-time":"2003-05-19T11:34:21Z","timestamp":1053344061000},"page":"17-20","source":"Crossref","is-referenced-by-count":6,"title":["Prolylhydroxylase and procollagen type III in long\u2010term survivors of acute lymphoblastic leukemia (ALL): A biochemical approach to HCV\u2010related liver disease"],"prefix":"10.1002","volume":"41","author":[{"given":"Salvatore","family":"Leonardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"La Spina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"La Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino","family":"Schilir\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,5,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)90518-9"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006454-199603000-00018"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954518"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980915)83:6<1224::AID-CNCR23>3.0.CO;2-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199903113401001"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199302000-00008"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040506"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90929-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(86)90333-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1093\/clinchem\/34.4.715","article-title":"Rapid equilibrium radioimmunoassay of the aminoterminal propeptide of human type III procollagen","volume":"34","author":"Risteli J","year":"1988","journal-title":"Clin Chem"},{"key":"e_1_2_1_12_2","first-page":"914","article-title":"Acute and chronic hepatitis revisited","author":"Bianchi L","year":"1997","journal-title":"Lancet"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90084-O"},{"key":"e_1_2_1_14_2","first-page":"1437","article-title":"Procollagen\u2010III peptide and chronic viral C hepatitis","volume":"90","author":"Jeffers LJ","year":"1995","journal-title":"Am J Gastr"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(05)80018-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1182\/blood.V93.11.3672.411k04_3672_3677","article-title":"Chronic hepatitis C virus infections in leukemia survivors: Prevalence, viral load, and severity of liver disease","volume":"93","author":"Paul IM","year":"1999","journal-title":"Blood"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1182\/blood.V93.4.1127","article-title":"Hepatitis viruses and hematopoietic cell transplantation. 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