{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:18:54Z","timestamp":1790687934864,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,7,11]],"date-time":"2003-07-11T00:00:00Z","timestamp":1057881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Only limited data are available on the effects of radiation\u2010therapy on the mineral content of the bone of children treated for malignancy. The incidence of osteopenia varies between 8 and 23%, but confounding factors were the use of chemotherapy and the effects of prophylactic cranial irradiation. The factors influencing bone atrophy are no more clearly defined in adults treated for cancer by high dose local radiation\u2010therapy. Pathological observed in patient tissues, indicates a clear role for vascular changes in the development of osteopenia, although there remains some uncertainty as to the effects of osteoblast cell loss. Reduced blood flow in bone is clearly dose\u2010related in experimental animal studies and after single doses of &gt;20 Gy changes in bone mineral content have been found. However, this was only at late times (\u226530 weeks) after irradiation. The relationship between these changes and bone strength remains unproven because of the limited nature of many of the animal studies. Radiation dose fractionation data for rib\u2010fracture in breast cancer patients suggests an \u03b1\/\u03b2 ratio is in the range 1.8\u20132.8 Gy, comparable to values obtained for other late responding normal human tissues. Med Pediatr Oncol 2003;41:208\u2013211. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.10338","type":"journal-article","created":{"date-parts":[[2003,7,14]],"date-time":"2003-07-14T06:09:16Z","timestamp":1058162956000},"page":"208-211","source":"Crossref","is-referenced-by-count":180,"title":["Radiation\u2010therapy effects on bone density"],"prefix":"10.1002","volume":"41","author":[{"given":"John W.","family":"Hopewell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,7,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-46794-3_31"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199904)32:4<272::AID-MPO6>3.0.CO;2-G"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80536-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.71.4.346"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199807000-00008"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199611000-00006"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650111122"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-66-789-814"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199805000-00009"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-46794-3_33"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1148\/117.3.677"},{"key":"e_1_2_1_13_2","first-page":"87","article-title":"Ver\u00e4nderungen von mineralgehalt und struktur des femur nach gyakologischer stralentherapie","volume":"66","author":"Heuch F","year":"1967","journal-title":"Stralentherapie"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(02)00002-6"},{"key":"e_1_2_1_15_2","first-page":"225","article-title":"Post\u2010irradiation atrophy of mature bone","volume":"12","author":"Ergun H","year":"1980","journal-title":"CRC Crit Rev Diagn Imag"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418512600600135"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1152\/physrev.1944.24.2.225","article-title":"Histopathology of radiation lesions","volume":"24","author":"Warren S","year":"1944","journal-title":"Physiol Rev"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1960.03770050053008"},{"key":"e_1_2_1_19_2","first-page":"101","volume-title":"Biological basis of radiotherapy","author":"Hopewell JW","year":"1989"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1080\/09553006614550181"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841868309134038"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/02841859809172147","article-title":"Bone fragility induced by X\u2010ray irradiation in relation to cortical bone\u2010mineral content","volume":"39","author":"Nyaruba MM","year":"1998","journal-title":"Acta Radiol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00339-3"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841868809090331"},{"key":"e_1_2_1_25_2","unstructured":"1987 Taylor & Francis London HD Thames JH Hendry Fractionation in radiotherapy"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.10338","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.10338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T21:20:54Z","timestamp":1700256054000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.10338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7,11]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1002\/mpo.10338"],"URL":"https:\/\/doi.org\/10.1002\/mpo.10338","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,7,11]]}}}