{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:16Z","timestamp":1786978216241,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2003,6,19]],"date-time":"2003-06-19T00:00:00Z","timestamp":1055980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2003,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this retrospective review is to evaluate our experience using radiosurgery in the management of craniopharyngiomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      Fourteen patients, 6 males and 8 females, ages ranging from 3 to 44 years of age, were treated with radiosurgery from February 1994 through December 2000 for primary or recurrent craniopharyngioma. There were two adults and 12 children. All patients were treated with the Leksell Gamma units Model U or C. The mean minimum dose was 14 Gy ranging from 11 to 20 Gy and the mean maximum dose was 29 Gy ranging from 24 to 40 Gy. Volume of treatment ranged from 0.1 to 26.5 cm\n                      <jats:sup>3<\/jats:sup>\n                      . The dose to critical structures was below 8 Gy to the optic chiasm and below 14 Gy to the brain stem. One of the 14 patients had previous conventional radiation therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All patients are alive and with out evidence of recurrent disease 6\u201386 months after treatment. Only two patients required retreatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Although craniopharyngioma is a benign tumor, its location makes even advanced microsurgical techniques difficult to perform. Radiosurgery obviates the shortcomings of surgical resection near the hypothalamic\u2010pituitary axis without the morbidity of open surgery. Med Pediatr Oncol 2003;41:123\u2013127. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mpo.10364","type":"journal-article","created":{"date-parts":[[2003,6,20]],"date-time":"2003-06-20T06:20:01Z","timestamp":1056090001000},"page":"123-127","source":"Crossref","is-referenced-by-count":66,"title":["Role of radiosurgery in craniopharyngiomas: A preliminary report"],"prefix":"10.1002","volume":"41","author":[{"given":"Beatriz E.","family":"Amendola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizik","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sammie R.","family":"Coy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Amendola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,6,19]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1707","article-title":"Stereotactic radiosurgery and radiotherapy: New developments and new directions","volume":"29","author":"Corn BW","year":"1997","journal-title":"Semin Oncol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(99)80002-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1969.30.4.0377"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120861"},{"key":"e_1_2_1_6_2","first-page":"409","volume-title":"Neuro\u2010oncology: The essentials","author":"Moore DK","year":"2000"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-4296(05)80019-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1996.85.1.0073"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.1.0047"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120860"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120858"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.1.0003"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.90.2.0237"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90705-M"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197501)35:1<111::AID-CNCR2820350116>3.0.CO;2-#"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120870"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8529(18)30468-7"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80254-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1999.90.2.0251"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1990.73.4.0534"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357908509039812"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","unstructured":"KobayashiT TanakaT KidaY.Stereotactic gamma radiosurgery of craniopharyngiomas Pediatric Neurosurgery1994;21(Suppl):69\u201374.","DOI":"10.1159\/000120865"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056450"},{"issue":"3","key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3171\/jns.2000.93.supplement_3.0047","article-title":"Gamma knife radiosurgery for craniopharyngiomas","volume":"93","author":"Chung WY","year":"2000","journal-title":"J Neurosurg"},{"key":"e_1_2_1_25_2","first-page":"15","volume-title":"Clinical radiation oncology","author":"Powell SN","year":"2000"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90080-F"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90326-F"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000056416"},{"key":"e_1_2_1_29_2","first-page":"516","article-title":"Management of craniopharyngioma","volume":"7","author":"Isaac MA","year":"2001","journal-title":"The Cancer J"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-3-3-159"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1080\/02688699943457"},{"key":"e_1_2_1_32_2","first-page":"1","article-title":"A therapeutic trial with radioactive isotopes in cystic brain tumour. 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