{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:16:30Z","timestamp":1740104190557,"version":"3.37.3"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,2,28]],"date-time":"2001-02-28T00:00:00Z","timestamp":983318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Terry Fox Research Foundation"},{"DOI":"10.13039\/501100008995","name":"Turkish Association Cancer Research and Control","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008995","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to analyse the expression of adhesion molecules in childhood non\u2010Hodgkin lymphomas and to correlate the findings with clinical features and prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Samples were obtained from pleural and peritoneal fluids, bone marrow aspirates, and tissue biopsies from 21 patients (median age: 8 years). There were 9 T\u2010cell and 12 B\u2010cell lymphomas. The expression of CD18, CD44s, CD54, CD62L were investigated with flow cytometry by using monoclonal antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Absence of CD18, which was independent from immunophenotype, was found in 67% of patients. Positive CD44s and CD62L expression were observed in 48 and 63% of the cases, respectively. In all of the cases with T\u2010cell lymphoma, CD54 was negative, whereas 8 of 12 cases with B\u2010cell lymphoma expressed this molecule (<jats:italic>P<\/jats:italic>\u2009=\u20090.005). There was no correlation between location of disease and the expression of adhesion molecules, except CD54 that was negative in all mediasten lymphoma (<jats:italic>P<\/jats:italic>\u2009=\u20090.004). CD62L (+) patients had more frequently stage IV disease than CD62L (\u2212) ones (<jats:italic>P<\/jats:italic>\u2009=\u20090.01). Two\u2010year overall survival was 83 and 29% in CD18 (+) and CD18 (\u2212) cases; 55 and 36% in CD44s (+) and CD44s (\u2212) cases; 46 and 42% in CD54 (+) and CD54 (\u2212) cases; 42 and 50% in CD62L (+) and CD62L (\u2212) cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The expression of LFA\u20101 on lymphoblasts is lost in the majority of childhood non\u2010Hodgkin lymphomas. ICAM\u20101 is not detected on neoplastic cells of patients with T\u2010cell lymphoblastic lymphoma. L\u2010selectin positivity correlates with disseminated disease. There is no significant relationship between the expression of adhesion molecules and the survival rates, although CD18(+) cases had better overall survival rate than CD18(\u2212) cases. Med. Pediatr. Oncol. 36:359\u2013364, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpo.1086","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T18:04:33Z","timestamp":1030298673000},"page":"359-364","source":"Crossref","is-referenced-by-count":6,"title":["Expression of adhesion molecules LFA\u20101, ICAM\u20101, CD44, and L\u2010selectin in childhood non\u2010Hodgkin lymphomas"],"prefix":"10.1002","volume":"36","author":[{"given":"Nilg\u00fcn","family":"Yaris","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcnevver","family":"B\u00fcy\u00fckpamuk\u00e7u","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emin","family":"Kansu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hande","family":"Canpinar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,2,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606063342308"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199602000-00001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/346425a0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607043350108"},{"key":"e_1_2_1_6_2","first-page":"36","article-title":"Endothelial\u2010leukocyte adhesion molecules in human disease","volume":"45","author":"Bevilacqua MP","year":"1994","journal-title":"Annu Rev Med"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199202000-00019"},{"key":"e_1_2_1_8_2","first-page":"4","article-title":"Biology of disease: Role of integrins and other cell adhesion molecules in tumour progression and metastasis","volume":"68","author":"Albelda SM","year":"1993","journal-title":"Lab Invest"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00046840"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199509056848"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90003-5"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60889-5"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(92)90151-V"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5258.60"},{"key":"e_1_2_1_15_2","first-page":"318","article-title":"Expression and function of adhesion receptors on normal B cells and B cell non\u2010Hodgkin lymphomas","volume":"30","author":"Freedman AS","year":"1993","journal-title":"Semin Hematol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1994.tb01870.x"},{"key":"e_1_2_1_17_2","first-page":"496","article-title":"Expression of lymphocyte homing receptor antigen in non\u2010Hodgkin lymphoma","volume":"130","author":"Picker LJ","year":"1988","journal-title":"Am J Pathol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1200\/JCO.1998.16.1.35","article-title":"Expression of the adhesion molecule ICAM\u20101 in non\u2010Hodgkin lymphoma: relationship with tumour dissemination and prognostic importance","volume":"16","author":"Terol JM","year":"1988","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_19_2","first-page":"332","article-title":"Classification, staging and end results of the treatment of childhood non\u2010Hodgkin's lymphoma: dissimilarities from lymphomas in adults","volume":"7","author":"Murphy SB","year":"1980","journal-title":"Semin Oncol"},{"key":"e_1_2_1_20_2","first-page":"358","article-title":"Results of the LMB 89 protocol for childhood B cell lymphomas and leukemia. 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