{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:02:08Z","timestamp":1791403328544,"version":"4.3.3"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,8,3]],"date-time":"2001-08-03T00:00:00Z","timestamp":996796800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Invasive fungal disease is a major cause of death in immunocompromised patients. The filamentous fungus Scedosporium consists of two species, <jats:italic>S. prolificans<\/jats:italic> and <jats:italic>S. apiospermum<\/jats:italic>, which can cause infections in immunocompromised patients that are often fatal. A significant feature of this pathogen is its broad resistance to many antifungal agents, including amphotericin B.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure and Results<\/jats:title><jats:p>Five cases of infection with <jats:italic>Scedosporium<\/jats:italic> spp. occurred in patients with haematologic malignancies over a 10\u2010month period. Three patients with <jats:italic>S. prolificans<\/jats:italic> were severely immunosuppressed and neutropenic; two were in relapse and another was early post\u2010matched unrelated bone marrow transplant. All three died despite treatment with various combinations of amphotericin B and itraconazole. Two patients who were less immunosuppressed and had a normal neutrophil count developed <jats:italic>S. apiospermum<\/jats:italic> infection. Both were successfully treated with liposomal amphotericin B and itraconazole.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Disseminated infection in immunocompromised hosts with <jats:italic>Scedosporium<\/jats:italic> spp. is often fatal. However, in patients with a lesser degree of immunocompromise and particularly in those infected with the less virulent <jats:italic>S. apiospermum<\/jats:italic>, intensive antifungal therapy with liposomal amphotericin B and itraconazole may be associated with complete eradication of infection. Med Pediatr Oncol 2001;37:122\u2013125. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpo.1180","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:41:50Z","timestamp":1030308110000},"page":"122-125","source":"Crossref","is-referenced-by-count":33,"title":["<i>Scedosporium<\/i> infection in immunocompromised patients: Successful use of liposomal amphotericin B and itraconazole"],"prefix":"10.1002","volume":"37","author":[{"given":"D.","family":"Barbaric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.J.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,8,3]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/17.Supplement_2.S487"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90255-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.5.1027"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.10.2138"},{"key":"e_1_2_1_6_2","first-page":"187","article-title":"Australian and New Zealand trials of acute lymphoblastic leukaemia of childhood","volume":"5","author":"Waters K","year":"1998","journal-title":"Int J Pediatr Hematol Oncol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.33.12.3290-3295.1995"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/43.1.149"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1128\/JCM.36.5.1436-1438.1998","article-title":"Use of voriconazole in treatment of Scedosporium apiospermum infection: Case report","volume":"36","author":"Girmenia C","year":"1998","journal-title":"J Clin Microbiol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199902000-00010"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/clind\/16.5.731"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.1180","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.1180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:55:03Z","timestamp":1700412903000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.1180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1002\/mpo.1180"],"URL":"https:\/\/doi.org\/10.1002\/mpo.1180","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}