{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:09:29Z","timestamp":1777486169020,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2001,9,18]],"date-time":"2001-09-18T00:00:00Z","timestamp":1000771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Groningen Foundation for Pediatric Oncology Research (SKOG)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2001,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Children treated for acute lymphoblastic leukemia (ALL) often complain about handwriting problems.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Using a computerized writing task, we have prospectively studied the processes necessary for the production of handwriting movements in 11 children (5\u201312 years old) during treatment for ALL. Children were tested at time points closely related to the vincristine administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and Conclusions<\/jats:title><jats:p>Children treated for ALL drew slower, with longer pause durations and increased drawing pressure. Children were able to overcome the problems, except for a consistently increased drawing pressure. This increased drawing pressure may be an attempt of the children to obtain sufficient kinesthetic information and thus can be seen as an adequate adaptation mechanism in case of peripheral neuropathy due to the neurotoxic effects of vincristine. However, neurotoxic effects of other cytostatic drugs cannot be excluded. Med Pediatr Oncol 2001;37:393\u2013399. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpo.1216","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:23:24Z","timestamp":1030310604000},"page":"393-399","source":"Crossref","is-referenced-by-count":33,"title":["Analysis of handwriting of children during treatment for acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"37","author":[{"given":"H.A.","family":"Reinders\u2010Messelink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Schoemaker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.A.B.","family":"Snijders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.N.H.","family":"G\u00f6eken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.M.","family":"B\u00f6kkerink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.A.","family":"Kamps","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,9,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02072486"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199808)31:2<86::AID-MPO7>3.0.CO;2-V"},{"key":"e_1_2_1_4_2","first-page":"215","volume-title":"Handwriting and drawing research: Basic and applied issues","author":"Reinders\u2010Messelink H","year":"1996"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199912)33:6<545::AID-MPO4>3.0.CO;2-Y"},{"key":"e_1_2_1_6_2","first-page":"353","article-title":"Specific learning problems among children treated for acute lymphoblastic leukemia","volume":"4","author":"Cousens P","year":"1997","journal-title":"Int J Ped Hemat\/Oncol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/87565649409540566"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/96.1.69"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910501)67:9<2241::AID-CNCR2820670905>3.0.CO;2-A"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/1040-8428(93)90006-P"},{"key":"e_1_2_1_11_2","volume-title":"Movement assessment battery for children","author":"Henderson SE","year":"1992"},{"key":"e_1_2_1_12_2","first-page":"45","volume-title":"Contemporary issues in the forensic developmental and neurological aspects of handwriting","author":"Schoemaker MM","year":"1994"},{"key":"e_1_2_1_13_2","first-page":"65","volume-title":"Contemporary issues in the forensic developmental and neurological aspects of handwriting","author":"Kooistra L","year":"1994"},{"key":"e_1_2_1_14_2","first-page":"17","volume-title":"Contemporary issues in the forensic developmental and neurological aspects of handwriting","author":"Smits\u2010Engelsman BCM","year":"1994"},{"key":"e_1_2_1_15_2","first-page":"O","article-title":"Results of the DCLSG\u2010STUDY ALL8 (1991\u20131997): BFM\u2010oriented treatment without cranial irradiation (CI) and comparing conventional oral and high doses intravenous 6\u2010mercaptopurine","volume":"33","author":"Kamps WA","year":"1999","journal-title":"Med Pediatr Oncol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1046607"},{"key":"e_1_2_1_17_2","first-page":"429","volume-title":"Handwriting and drawing research: basic and applied issues","author":"de Jong WP","year":"1996"},{"key":"e_1_2_1_18_2","volume-title":"Hierarchical linear models, Applications and data analysis methods","author":"Bryk AS","year":"1992"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00170145"},{"key":"e_1_2_1_20_2","volume-title":"Mulitilevel statistical models","author":"Goldstein H","year":"1995"},{"key":"e_1_2_1_21_2","volume-title":"Multilevel modelling applications. A guide for users of MLn","author":"Woodhouse G","year":"1996"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-9457(98)00014-1"},{"key":"e_1_2_1_23_2","volume-title":"MLn command reference","author":"Rasbash J","year":"1995"},{"key":"e_1_2_1_24_2","volume-title":"Medical Uses of Statistics","author":"Bailar JC","year":"1992"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejpn.1999.0310"},{"key":"e_1_2_1_26_2","first-page":"13.1","volume-title":"Handbook of perception and human performance, Vol. 1: Sensory processes and performance","author":"Clark FJ","year":"1986"},{"key":"e_1_2_1_27_2","first-page":"41","article-title":"Axial pen pressure during handwriting movements in conditions with and without vision","volume":"23","author":"van Doorn RA","year":"1992","journal-title":"J Hum Mov Stud"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-9457(86)90032-1"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4115(08)60627-5"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4115(09)60071-6"},{"key":"e_1_2_1_31_2","first-page":"569","article-title":"Postural organization in patients with hereditary motor and sensory neuropathy","volume":"73","author":"Geurts ACH","year":"1992","journal-title":"Arch Phys Medi Rehabil"},{"key":"e_1_2_1_32_2","first-page":"187","volume-title":"Advances in handwriting and drawing. A multidisciplinary approach","author":"Smits\u2010Engelsman BCM","year":"1994"},{"key":"e_1_2_1_33_2","first-page":"247","volume-title":"Advances in handwriting and drawing: a multidisciplinary approach","author":"Kosterman BJM","year":"1994"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1080\/87565649209540512"},{"key":"e_1_2_1_35_2","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association, APA","year":"1994"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30259-7"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpepsy\/13.2.183"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.1216","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.1216","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T16:47:08Z","timestamp":1700412428000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.1216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9,18]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,10]]}},"alternative-id":["10.1002\/mpo.1216"],"URL":"https:\/\/doi.org\/10.1002\/mpo.1216","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,9,18]]}}}