{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:15:19Z","timestamp":1761707719738},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,11,16]],"date-time":"2001-11-16T00:00:00Z","timestamp":1005868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The authors have revealed a significant association between hepatoblastoma and low birth weight. This study was done to explore the evidence that liver cells were oxidatively damaged, based on the hypothesis that oxidative damage to DNA is involved in the development of hepatoblastoma in children of low birth weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Procedure<\/jats:title><jats:p>Oxidative DNA damage in the liver was examined by immunohistochemically detecting the presence of a DNA repair product, 8\u2010hydroxy\u20102\u2032\u2010deoxyguanosine (8\u2010OHdG), in five patients with hepatoblastoma and 14 children with non\u2010neoplastic disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive staining for 8\u2010OHdG was observed in all five patients with hepatoblastoma. Distribution of 8\u2010OHdG positivity was diffuse in the intralobular area in one patient and was restricted to the periportal area of the lobules in four patients. There was no apparent correlation between birth weight of the patients, histological findings in the liver, and the distribution of 8\u2010OHdG positivity. In children with non\u2010neoplastic disease, 8\u2010OHdG was detected in nine of 14 patients, and 8\u2010OHdG was positive in the intralobular area of the liver parenchyma except in one patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results suggest that the cause of oxidative DNA damage in patients with hepatoblastoma may be different from the cause, extensive parenchymal damage to the liver, in children with non\u2010neoplastic disease, but the 8\u2010OHdG formation is not specific to hepatoblastoma patients of low birth weight. Further studies to elucidate the true reason for the high incidence of hepatoblastoma in children of low birth weight are necessary. Med Pediatr Oncol 2001; 37:505\u2013510. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpo.1243","type":"journal-article","created":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T11:06:17Z","timestamp":1098875177000},"page":"505-510","source":"Crossref","is-referenced-by-count":9,"title":["Detection of hepatic oxidative DNA damage in patients with hepatoblastoma and children with non\u2010neoplastic disease"],"prefix":"10.1002","volume":"37","author":[{"given":"Hitoshi","family":"Ikeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Hirato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Kuroiwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Tsuchida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,11,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"474","article-title":"Congenital anomalies and childhood cancer in Great Britain","volume":"60","author":"Narod SA","year":"1997","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(97)70239-7"},{"key":"e_1_2_1_4_2","first-page":"3032","article-title":"Increased risk of hepatoblastoma among immature children with a lower birth weight","volume":"58","author":"Tanimura M","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980501)82:9<1797::AID-CNCR28>3.0.CO;2-Z"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.1999.01022.x"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-200x.2000.01287.x"},{"key":"e_1_2_1_8_2","first-page":"168","volume-title":"Pediatrics and perinatology","author":"Winterbourn CC","year":"1996"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072639"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.70.2.F107"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/fn.71.1.F40"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000244472"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00531-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(94)90332-8"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(97)00035-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00207507"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.24.9697"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/327077a0"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(94)80240-8"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.4.831"},{"key":"e_1_2_1_21_2","first-page":"3171","article-title":"Increased formation of oxidative DNA damage, 8\u2010hydroxydeoxyguanosine, in human livers with chronic hepatitis","volume":"54","author":"Shimoda R","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)48474-8"},{"key":"e_1_2_1_23_2","first-page":"6358","article-title":"p53 gene mutation spectrum in hepatocellular carcinoma","volume":"52","author":"Oda T","year":"1992","journal-title":"Cancer Res"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.1243","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.1243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T11:03:59Z","timestamp":1700391839000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.1243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,11,16]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["10.1002\/mpo.1243"],"URL":"https:\/\/doi.org\/10.1002\/mpo.1243","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"type":"print","value":"0098-1532"},{"type":"electronic","value":"1096-911X"}],"subject":[],"published":{"date-parts":[[2001,11,16]]}}}