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Pediatr. Oncol."],"published-print":{"date-parts":[[2001,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sex hormone deficiency, growth hormone deficiency, skeletal irradiation, and treatment with corticosteroids or methotrexate may all cause reduction in bone mass after treatment for childhood malignant lymphoma. Previous studies of the bone mass of childhood cancer survivors often lacked adequate local reference data, and survivors of malignant lymphoma were never analyzed separately.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Procedure<\/jats:title>\n                    <jats:p>The bone mass of survivors of childhood Hodgkin disease (n\u2009=\u200923) or non\u2010Hodgkin lymphoma (n\u2009=\u200921) was measured by dual\u2010energy X\u2010ray absorptiometry a median of 11 years after diagnosis (range 2\u201325). Results were compared with local data on 463 healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adjusted for gender and age, the mean whole\u2010body bone mineral content and bone mineral areal density were slightly, but significantly, reduced (0.5 and 0.4 SD lower than predicted). The reduced bone mineral content was associated with a significantly reduced height, whereas the size\u2010adjusted bone mass (bone mineral content for bone area) did not differ significantly from that of controls. Lower height was related to male gender and to cranial, thoracic, and lumbar spine irradiation. Whole\u2010body bone mineral content and bone mineral density were lower in persons treated with lumbar spine irradiation and whole\u2010body bone mineral content was higher in nine women receiving sex hormone replacement therapy or oral contraceptives. Whole\u2010body bone mass was not related to the cumulated doses of corticosteroids or methotrexate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Eleven years after diagnosis of childhood Hodgkin disease or non\u2010Hodgkin lymphoma, the whole\u2010body bone mass of survivors was only slightly reduced and the size\u2010adjusted bone mass was normal. Med Pediatr Oncol 2001;37:518\u2013524. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mpo.1245","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T16:14:25Z","timestamp":1030292065000},"page":"518-524","source":"Crossref","is-referenced-by-count":32,"title":["Bone mass after treatment of malignant lymphoma in childhood"],"prefix":"10.1002","volume":"37","author":[{"given":"Karsten","family":"Nysom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Holm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Fleischer","family":"Michaelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"M\u00f8lgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2001,11,16]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13636.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1350135"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000184765"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00420-P"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301143280211"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1370240"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.10.3441"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197003)25:3<580::AID-CNCR2820250313>3.0.CO;2-M"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197602)37:2 <1048::AID-CNCR2820370811>3.0.CO;2-V"},{"key":"e_1_2_1_11_2","first-page":"489","article-title":"Methotrexate\u2010induced bone pain in childhood leukemia","volume":"126","author":"O'Regan S","year":"1973","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_12_2","first-page":"63","article-title":"Osteopathy due to methotrexate","volume":"3","author":"Koller A","year":"1976","journal-title":"Osterr Kneipp Mag"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199611000-00006"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199805000-00010"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199807000-00008"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(1998)78:11 <44::AID-IJC13>3.0.CO;2-A"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199904)32:4<272::AID-MPO6>3.0.CO;2-G"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199904010-00014"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199804)30:4<240::AID-MPO6>3.0.CO;2-G"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.1.9"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.1.10"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841859809175488"},{"key":"e_1_2_1_23_2","first-page":"163","article-title":"Growth, growth hormone and final height after BMT. 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