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These patients received the L\u2010asparaginase for 8, 14, 27, and 34+ months without demonstrating any significant adverse effects. Only 1 of the 4 was clearly resistant to the other chemotherapy, and 3 of 4 had recurrence of their disease while receiving L\u2010asparaginase. L\u2010asparaginase can be added to reinduction and maintenance regimens of patients resistant to other chemotherapy and is well tolerated for long periods when given intramuscularly weekly with other immunosuppressant agents.<\/jats:p>","DOI":"10.1002\/mpo.2950020314","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T14:12:23Z","timestamp":1171980743000},"page":"327-332","source":"Crossref","is-referenced-by-count":2,"title":["L\u2010asparaginase reinduction and maintenance therapy in previously treated acute lymphocytic leukemia"],"prefix":"10.1002","volume":"2","author":[{"given":"Lance","family":"Sieger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gussie","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nomie","family":"Shore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1967.03130220070012"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5683.596"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197002)25:2<306::AID-CNCR2820250206>3.0.CO;2-H"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196911062811902"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1971)28:4<819::AID-CNCR2820280403>3.0.CO;2-9"},{"key":"e_1_2_1_7_2","first-page":"942","article-title":"L\u2010asparaginase in the treatment of neoplastic diseases in children","volume":"31","author":"Jaffe N.","year":"1971","journal-title":"Cancer Res."},{"key":"e_1_2_1_8_2","first-page":"363","article-title":"Effective combination treatment of advanced acute lymphocytic leukemia with cytosine arabinoside and L\u2010asparaginase","volume":"56","author":"Ortega J. 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