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Oncol."],"published-print":{"date-parts":[[1976,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Six regimens utilizing L\u2010asparaginase in doses of 6,000 IU\/M<jats:sup>2<\/jats:sup>, 2,000 IU\/M<jats:sup>2<\/jats:sup>, and 500 IU\/M<jats:sup>2<\/jats:sup> in two separate schedules (consecutive and intermittent) along with vincristine and prednisone yielded remarkably similar response rates, approximating 70%, in 306 previously treated children with acute leukemia in relapse. The addition of daunorubicin to one regimen did not alter the response rate. Hypersensitivity reactions occurred in 5% and hyperglycemia in 7%. Lower doses of L\u2010asparaginase significantly reduced the hypersensitivity rate but no such pattern was noted for hyperglycemia. 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