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Both BCNU and procarbazine are known to cross the blood\u2010brain barrier. Procarbazine is known to interfere with neurological function. BCNU has been reported to transiently interfere with vision and, although this patient had highly morbid disease, the onset of optic neuroretinitis 8 days after combination therapy with these 2 drugs raises the possibility that one or both in combination may have been the cause of the optic neuropathy.<\/jats:p>","DOI":"10.1002\/mpo.2950040108","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:01:35Z","timestamp":1171983695000},"page":"43-48","source":"Crossref","is-referenced-by-count":23,"title":["Optic neuroretinitis in association with BCNU and procarbazine therapy"],"prefix":"10.1002","volume":"4","author":[{"given":"R.","family":"Mc. Lennan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. 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