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Adenocarcinomas of the lung or ovary were the most common tumors (48%), followed by hematologic malignancies (25%). Five patients had acute leukemia, two of whom had received bone marrow transplantation. Sudden changes in the status of cardiovascular and central nervous sytems were the most common manifestations of NBTE and its complications. The possible predisposing factors included disseminated malignant neoplasms and infection with gram\u2010negative bacilli. Identification of high\u2010risk patients and early administration of preventive measures including anticoagulation might decrease the morbidity and mortality related to NBTE.<\/jats:p>","DOI":"10.1002\/mpo.2950040211","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:00:25Z","timestamp":1171983625000},"page":"149-157","source":"Crossref","is-referenced-by-count":31,"title":["Nonbacterial thrombotic endocarditis in cancer patients: Comparison of characteristics of patients with and without concomitant disseminated intravascular coagulation"],"prefix":"10.1002","volume":"4","author":[{"given":"Agop","family":"Bedikian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Valdivieso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Luna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald P.","family":"Bodey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.125.1.126"},{"key":"e_1_2_1_3_2","first-page":"393","volume-title":"Disseminated Intravascular Coagulation","author":"McKay DG","year":"1965"},{"key":"e_1_2_1_4_2","first-page":"65","article-title":"Nonbacterial thrombotic endocarditis (NBTE) and disseminated intravascular coagulation (DIC)","volume":"101","author":"Kim HS","year":"1977","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_5_2","first-page":"255","article-title":"The significance of nonbacterial thrombotic endocarditis. 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