{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:37:27Z","timestamp":1778629047065,"version":"3.51.4"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":10062,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Full skeletal survey was performed on 193 consecutive children presenting over a 6\u2010year period with acute lymphoblastic leukaemia (ALL). A record was made of the degree of bone pain in these patients and 60 others presenting immediately prior to the availability of skeletal surveys. Bone pain was present in 76 out of 253 patients (30%) and radiological bone changes characteristic of leukaemia in 125 out of 193 (65%). A significant correlation was found between the severity of bone pain and the number of bones involved on \u00d7 ray (r = 0.25, P = &lt;0.001), but not between initial white cell counts and bone score (r =\u20100.14, P = 0.08). There was no significant correlation between the degree of bone pain and survival or length of first remission (P = 0.29 and 0.86). Similarly, the extent of radiological bone disease was of no prognostic significance with relation to survival (P = 0.41) or length of first remission (P = 0.21).<\/jats:p>","DOI":"10.1002\/mpo.2950060108","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T14:57:05Z","timestamp":1171983425000},"page":"51-55","source":"Crossref","is-referenced-by-count":39,"title":["The prognostic significance of radiological and symptomatic bone involvement in childhood acute lymphoblastic leukaemia"],"prefix":"10.1002","volume":"6","author":[{"given":"Ian M.","family":"Hann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subash","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia H.","family":"Morris\u2010Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.7.530"},{"key":"e_1_2_1_3_2","first-page":"83","article-title":"Routine whole skeleton x\u2010ray investigation of 116 children with leukaemia","volume":"19","author":"Bellini F","year":"1976","journal-title":"Ann Radiol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1182\/blood.V23.4.526.526","article-title":"Reticulin fibrosis and bone infarction in acute leukaemia implications for prognosis","volume":"23","author":"Kundel DW","year":"1964","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-62-4-698"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1972.02110170031004"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(199005\/06)14:3<608::AID-CNCR2820140322>3.0.CO;2-X"},{"key":"e_1_2_1_8_2","unstructured":"Hayhoe FGJ Qualgino D Doll R (eds): \u201cThe Cytology and Cytochemistry of Acute Leukaemias.\u201d Medical Research Council Special Report Series 304 1964."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1148\/72.5.672"},{"key":"e_1_2_1_11_2","first-page":"819","article-title":"The skeletal lesions in leukaemia, clinical and x\u2010ray observations in 103 infants and chldren","volume":"59","author":"Silverman FN","year":"1948","journal-title":"Am J Roentgenol Radium Therap Nucl Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0033-8389(22)02795-6","article-title":"The osseous manifestations of leukaemia in children","volume":"6","author":"Simmons CR","year":"1968","journal-title":"Radiol Clin North Am"},{"key":"e_1_2_1_13_2","first-page":"863","article-title":"Vertebral compression in childhood leukaemia","volume":"125","author":"Newman AJ","year":"1973","journal-title":"Am J Dis Child"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950060108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950060108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:39:28Z","timestamp":1699828768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950060108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/mpo.2950060108"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950060108","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}