{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T22:08:00Z","timestamp":1765231680874},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":10062,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirty\u2010six febrile neutropenic episodes were treated by granulocyte transfusions in 33 children. Septicemia and mucous membrane ulcerations were most commonly associated with the fever. Infection cleared in 81% of the episodes, eight per cent ended in death from bacterial infections, 11% from nonbacterial infections or hemorrhage. The median number of polymorphonuclear leukocytes given was 1.1 \u00d7 10<jats:sup>10<\/jats:sup>\/m<jats:sup>2<\/jats:sup>\/transfusion. Two to twenty\u2010eight (median 8.5) transfusions were given over 3\u201334 days (median 10.5). The source of cells (parental or random) and the method of collection did not seem to affect the outcome. None of the 23 patients whose marrow recovered during the transfusions died of bacterial infections. Infection cleared even without marrow recovery in 62% of the patients, but then only 25% lived for more than two months after clearing of sepsis. In a subgroup of patients with nonlymphoblastic leukemia on the same chemotherapy and antibiotic treatment protocol, 8\/11 (73%) survived bacteremia when white cell support was available; only 2\/11 (18%) of a historical control group survived when such support was not available. Granulocyte support appears to be a valuable tool in helping neutropenic patients overcome their infections or, at the very least, helping them survive long enough for normal marrow recovery to occur.<\/jats:p>","DOI":"10.1002\/mpo.2950060110","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T14:57:05Z","timestamp":1171983425000},"page":"65-76","source":"Crossref","is-referenced-by-count":6,"title":["Granulocyte transfusions in infected neutropenic children with malignancies"],"prefix":"10.1002","volume":"6","author":[{"given":"Peter G.","family":"Steinherz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian M.","family":"Reich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-64-2-328"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197208242870801"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197703312961302"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197405092901906"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197703312961301"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01005305"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.26.020175.001445"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197609)38:3<1407::AID-CNCR2820380347>3.0.CO;2-S"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1976.16376225492.x"},{"key":"e_1_2_1_11_2","unstructured":"ReichLM VonSickleP WrightP:Granulocyte transfusion: A preliminary study. In \u201cLeukocytes: Sepration collection and transfusion. Proceedings of the International Symposium on Leukocyte Separation and Transfusion.\u201d London September1974 pp294\u2013299."},{"key":"e_1_2_1_12_2","volume-title":"American Association of Blood Banks Technical Methods and Procedures","author":"Miller V","year":"1974"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92874-6"},{"key":"e_1_2_1_14_2","unstructured":"SandersJ WilburJR LongT EtcubanasE BabinS GrantJ:Granulocyte transfusions in the treatment of infection in children with malignancy. In \u201cProceedings of the Eleventh Annual Meeting of the American Society of Clinical Oncology.\u201d San Diego May1975 p269."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1976.16476247054.x"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1182\/blood.V48.1.149.149","article-title":"Degranulation and abnormal bacterial function of granulocytes procured by reversible adhesion to nylon wool","volume":"48","author":"Klok JC","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1977.17277151917.x"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950060110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950060110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:39:36Z","timestamp":1699828776000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950060110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/mpo.2950060110"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950060110","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}