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Changes in mentation, increased frequency and intensity of flushing, and hypotension indicate increased risk of a chemotherapy induced carcinoid crisis. Since prednisone may produce relatively long control of carcinoid syndrome, it should be tried before chemotherapy in patients who have increased risk of carcinoid crisis. If chemotherapy is given, doses should be decreased by 50%, and patients should be followed closely.<\/jats:p>","DOI":"10.1002\/mpo.2950060111","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T14:57:05Z","timestamp":1171983425000},"page":"77-83","source":"Crossref","is-referenced-by-count":10,"title":["Management of carcinoid syndrome"],"prefix":"10.1002","volume":"6","author":[{"given":"Philip","family":"Bonomi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Hovey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Dainauskas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Slayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Wolter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"issue":"11","key":"e_1_2_1_2_2","first-page":"3","article-title":"Carcinoid APUDomas","volume":"1","author":"Jagar RM","year":"1977","journal-title":"Current Problems in Cancer."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196109\/10)14:5<901::AID-CNCR2820140502>3.0.CO;2-Q"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(54)90152-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(56)90136-X"},{"key":"e_1_2_1_6_2","first-page":"637","article-title":"The malignant carcinoid syndrome","volume":"137","author":"Davis Z","year":"1973","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.11.2.189"},{"key":"e_1_2_1_8_2","first-page":"293","article-title":"Pharmacological blockade of carcinoid flushing provoked by cathecholamines and alcohol","volume":"2","author":"Adamson AR","journal-title":"Lancet"},{"key":"e_1_2_1_9_2","first-page":"329","article-title":"Carcinoid tumors","volume":"25","author":"Hill GJ","year":"1971","journal-title":"Pharmacol Therap"},{"key":"e_1_2_1_10_2","first-page":"182","article-title":"Adjuvant therapy of malignant carcinoid syndrome","volume":"54","author":"Mengel CE","year":"1963","journal-title":"Surgery"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-62-3-587"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197508)36:2 <675::AID-CNCR2820360810>3.0.CO;2-A"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197009)26:3<547::AID-CNCR2820260307>3.0.CO;2-J"},{"key":"e_1_2_1_14_2","first-page":"460","article-title":"Comparative effects of three nitrosourea derivatives on mammalian cell cycle progression","volume":"35","author":"Tobey RA","year":"1975","journal-title":"Cancer Res"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(65)90147-6"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(60)90256-7"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196208302670904"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(64)90565-3"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(65)90080-X"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950060111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950060111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T22:39:40Z","timestamp":1699828780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950060111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/mpo.2950060111"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950060111","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}