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Histologic diagnoses were reclassified as follows: 13 lymphoblastic (others) ML, 15 convoluted cell type lymphoblastic ML, 9 Burkitt type ML, and 7 immunoblastic ML. Only 36% of the patients had stage I and II disease. At diagnosis 25% showed malignant cells in the bone marrow smears. Bone marrow infiltration was particularly frequent in the convoluted cell type lymphoblastic ML and in the lymphoblastic (others) ML subgroups. Burkitt type ML frequently was associated with abdominal lesions and subsequently a high incidence of central nervous system involvement. Patients with stage I and II ML were encountered mostly in the immunoblastic ML subgroup. After 1973 more intensive chemotherapy plus radiotherapy seems to have slightly improved the survival of the patients, except in the Burkitt type ML subgroup.<\/jats:p>","DOI":"10.1002\/mpo.2950060309","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T14:56:01Z","timestamp":1171983361000},"page":"243-253","source":"Crossref","is-referenced-by-count":1,"title":["Childhood non\u2010Hodgkin malignant lymphomas: A clinicopathologic retrospective study"],"prefix":"10.1002","volume":"6","author":[{"given":"Marco","family":"Gasparini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franca","family":"Fossati\u2010Bellani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Lattuada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Pilotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Rilke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950010307"},{"key":"e_1_2_1_3_2","first-page":"1161","article-title":"The management of childhood non\u2010Hodgkin's lymphoma","volume":"61","author":"Murphy SB","year":"1977","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_4_2","first-page":"319","volume-title":"Malignant Diseases in Children","author":"Jenkin RDT","year":"1974"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197601)37:1<123::AID-CNCR2820370119>3.0.CO;2-7"},{"key":"e_1_2_1_6_2","first-page":"298","article-title":"Non\u2010Hodgkin's lymphoma children","volume":"31","author":"Pinkel D","year":"1975","journal-title":"Br J Cancer"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197106)27:6<1328::AID-CNCR2820270608>3.0.CO;2-A"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197407)34:1<204::AID-CNCR2820340131>3.0.CO;2-2"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1974.tb16990.x"},{"key":"e_1_2_1_10_2","first-page":"331","article-title":"Malignant non\u2010Hodgkin's lymphoma (NHL) in childhood","volume":"32","author":"Wagner HP","year":"1977","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820360928"},{"key":"e_1_2_1_12_2","first-page":"7","article-title":"Klassifikation der Non\u2010Hodgkin\u2010Lymphome im Kindesalter","volume":"189","author":"Lennert K","year":"1977","journal-title":"Klin P\u00e4ediatr"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:8 <1488::AID-CNCR2820340822>3.0.CO;2-C"},{"key":"e_1_2_1_14_2","first-page":"29","article-title":"Cytological and functional criteria for the classification of malignant lymphomata","volume":"31","author":"Lennert K","year":"1975","journal-title":"Br J Cancer"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197807)42:1<171::AID-CNCR2820420129>3.0.CO;2-R"},{"key":"e_1_2_1_16_2","first-page":"406","article-title":"Classification of non\u2010Hodgkin's lymphomas","volume":"2","author":"Gerard\u2010Marchant R","year":"1974","journal-title":"Lancet"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1177\/030089167806400211"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1978.tb01724.x"},{"key":"e_1_2_1_19_2","volume-title":"Tumors of the Hematopoietic System. 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