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A complete remission was achieved in 96% of children in relapse and in five out of six children resistant to induction. Remission was achieved without hospitalisation in over 60% of patients.<\/jats:p><jats:p>The median duration of subsequent remission was only 13 weeks, but six out of eight children receiving a second course of the drug combination achieved a further remission. We conclude that prolonged 1\u2010asparaginase therapy in combination with an anthracycline might well be used in initial or consolidation therapy for childhood ALL.<\/jats:p>","DOI":"10.1002\/mpo.2950060413","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T14:53:50Z","timestamp":1171983230000},"page":"359-365","source":"Crossref","is-referenced-by-count":33,"title":["Combination chemotherapy for bone marrow relapse in childhood lymphoblastic leukaemia (all)"],"prefix":"10.1002","volume":"6","author":[{"given":"Judith M.","family":"Chessells","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Cornbleet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2141.1976.tb03529.x","article-title":"Analysis of treatment in childhood leukaemia. 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