{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:08Z","timestamp":1760188868800},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":10062,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1979,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Four patients developed abnormal liver function tests and focal defects on liver scan while receiving cyclosphosphamide, methotrexate and 5\u2010fluorouracil as adjuvant chemotherapy following mastectomy for breast cancer. Liver biopsies showed severe focal inflammation. The biopsy findings and the subsequent clinical course of the patients strongly suggest that these abnormalities were due to hepatic toxicity of the chemotherapy and not metastic breast cancer. A review of serial liver function tests performed on 24 patients in that chemotherapy program revealed that four out of eight patients with elevated alkaline phosphatase prior to therapy developed early metastatic cancer. Elevated alkaline phosphatase occurring during chemotherapy on the other hand was quite common but more likely due to hepatic toxicity of the drugs. The development of abnormal liver function tests even in association with focal defects on liver scan is not sufficient to diagnose metastatic breast cancer in patients receiving adjuvant chemotherapy.<\/jats:p>","DOI":"10.1002\/mpo.2950070410","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:06:16Z","timestamp":1171983976000},"page":"351-359","source":"Crossref","is-referenced-by-count":11,"title":["Hepatic toxicity of adjuvant chemotherapy for carcinoma of the breast"],"prefix":"10.1002","volume":"7","author":[{"given":"William P.","family":"Vaughan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patti M.","family":"Wilcox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip O.","family":"Alderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Ettinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin D.","family":"Abeloff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501162920301"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197602192940801"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91719-6"},{"key":"e_1_2_1_5_2","first-page":"391","volume-title":"Breast Cancer","author":"Rossi A","year":"1977"},{"key":"e_1_2_1_6_2","first-page":"198","article-title":"Hepatic fibrosis in children with acute leukemia treated with folic acid antagonists","volume":"59","author":"Colsky J","year":"1955","journal-title":"Arch Pathol"},{"key":"e_1_2_1_7_2","first-page":"787","article-title":"Liver injury associated with methotrexate therapy for psoriasis","volume":"48","author":"Podurgiel BJ","year":"1973","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/jnci\/58.4.1011","article-title":"Hepatotoxicity in Wistar rats following chronic methotrexate administration: A model of human reaction","volume":"58","author":"Custer RP","year":"1977","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.111.1.165"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03060150035008"},{"key":"e_1_2_1_11_2","first-page":"227","article-title":"Liver scintigrams compared with alkaline phosphatase and BSP determinations in the detection of metastatic carcinoma","volume":"12","author":"Jhinran SG","year":"1971","journal-title":"J Nucl Med"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(77)90143-X"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1974162363"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.236.9.1023"},{"key":"e_1_2_1_15_2","first-page":"908","article-title":"Hepatic scintigraphy in clinical decision making","volume":"13","author":"Drum DE","year":"1972","journal-title":"J Nucl Med"},{"key":"e_1_2_1_16_2","first-page":"667","article-title":"Scintigraphic criteria for hepatic metastases from cancer of the colon and breast","volume":"17","author":"Drum DE","year":"1976","journal-title":"J Nucl Med"},{"key":"e_1_2_1_17_2","first-page":"450","article-title":"Are surgical adjuvant trials altering the course of breast cancer","volume":"5","author":"Bonnadonna G","year":"1978","journal-title":"Seminars in Oncology"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950070410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950070410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T04:30:59Z","timestamp":1699849859000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950070410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,1]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1979,1]]}},"alternative-id":["10.1002\/mpo.2950070410"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950070410","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,1]]}}}