{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T07:41:42Z","timestamp":1753602102614},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":9697,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1980,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soft agar culture studies of 43 immunologically characterized patients with childhood acute lymphocytic leukemia (ALL) are presented. The immunologic subsets studied include \u201cnull\u201d\u2010cell, pre\u2010B\u2010cell, and T\u2010cell leukemias. Abnormal myelopoiesis, including high peripheral blood and low marrow, colony\u2010forming cell numbers, low colony\u2010stimulating activity, and normal maturation of colony\u2010forming cells in vitro was noted in each group as previously described for immunologically uncharacterized ALL. We conclude that immunologic subsets of childhood lymphoblastic leukemia cause similar abnormalities of myelopoiesis. Lack of differences in growth characteristics among immunologic subsets of ALL make it impossible to use this tissue culture technique in sub\u2010classification of these leukemic disorders.<\/jats:p>","DOI":"10.1002\/mpo.2950080311","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:04:24Z","timestamp":1171983864000},"page":"289-294","source":"Crossref","is-referenced-by-count":2,"title":["Myelopoiesis in immunologically classified subgroups of childhood acute lymphocytic leukemia"],"prefix":"10.1002","volume":"8","author":[{"given":"William M.","family":"Crist","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelsalem H.","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Vogler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor K. S.","family":"Lui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Castleberry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Harry W.","family":"Findley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Merijanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1966.28"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1030660309"},{"key":"e_1_2_1_4_2","first-page":"249","volume-title":"Hematopoietic Cellular Proliferation","author":"Robinson WA","year":"1970"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.25.020174.001413"},{"issue":"6","key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1182\/blood.V41.6.753.753","article-title":"Granulopoiesis in neutropenic disorders","volume":"41","author":"Greenberg PL","year":"1973","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197403)33:3<791::AID-CNCR2820330326>3.0.CO;2-8"},{"issue":"4","key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1542\/peds.61.4.560","article-title":"\u201cLymphoblastic conversion\u201d of chronic myelogenous leukemia","volume":"61","author":"Crist WM","year":"1978","journal-title":"Pediatrics"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1542\/peds.61.6.889","article-title":"Granulopoiesis in chronic myeloproliferative disorders in children","volume":"61","author":"Crist WM","year":"1978","journal-title":"Pediatrics"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197106032842201"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(76)81116-X"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(75)80648-2"},{"key":"e_1_2_1_13_2","first-page":"149","article-title":"Marrow culture \u2014 A new approach to classification of leukemias","volume":"1","author":"Moore MAS","year":"1975","journal-title":"Blood cells"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-1229(77)90008-3"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4804(77)90102-0"},{"issue":"5","key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1542\/peds.56.5.788","article-title":"Lymphocyte surface receptors in childhood acute lymphocytic leukemia","volume":"56","author":"Esber E","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90361-0"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.141.5.1163"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804202981603"},{"key":"e_1_2_1_20_2","first-page":"407","volume-title":"Human Lymphocyte Differentiation: Its Application to Human Cancer","author":"Vogler L","year":"1978"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)92742-5"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.2.207"},{"key":"e_1_2_1_23_2","volume-title":"Non\u2010Parametrics: Statistical Methods Based on Ranks","author":"Lehmann EL","year":"1975"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950080311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950080311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:11:15Z","timestamp":1699845075000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950080311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["10.1002\/mpo.2950080311"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950080311","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,1]]}}}