{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T06:37:18Z","timestamp":1726123038653},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":9331,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sixteen children (ages 2\u201317) with acute promyelocytic leukemia (APL) were studied retrospectively. Diagnosis was based on clinical features and morphological criteria of the FAB classification. Bleeding diathesis was the predominant presenting symptom (&gt;85%), associated with laboratory findings of disseminated intravascular coagulation (DIC). Extramedullary manifestations included skin rash in six patients, gum infiltration in two, and meningeal leukemia in two. Induction therapy consisted of cytosine arabinoside and an anthracycline, with or without other agents. Prophylactic heparinization was given to 12 patients. Six patients (37.5%) failed to achieve remission and died, secondary to hemorrhage in three, and secondary to infection in the remaining three patients. The median duration of remission was 14 months, and the median survival for responders was 21 months. One meningeal leukemia preceded bone marrow relapse despite intermittent intrathecal chemotherapy for prophylaxis. Three patients remain in continuous complete remission 3 years after initial diagnosis.<\/jats:p><jats:p>Although childhood APL shares many features of its adult counterpart, the high frequency of extramedullary manifestations and mortality secondary to neutropenia deserves separate attention.<\/jats:p>","DOI":"10.1002\/mpo.2950090103","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:03:18Z","timestamp":1171983798000},"page":"5-15","source":"Crossref","is-referenced-by-count":26,"title":["Acute promyelocytic leukemia in children"],"prefix":"10.1002","volume":"9","author":[{"given":"Ka Wah","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.","family":"Steinherz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950010107"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(74)80037-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910200608"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-2-261"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197806)41:6<2484::AID-CNCR2820410659>3.0.CO;2-#"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1182\/blood.V41.4.489.489","article-title":"Acute promyelocytic leukemia \u2013 Results of treatment by daunorubicin","volume":"41","author":"Bernard J","year":"1973","journal-title":"Blood"},{"key":"e_1_2_1_8_2","first-page":"116","article-title":"Acute promyelocytic leukemia","volume":"61","author":"Armitage JO","year":"1964","journal-title":"Rocky Mt Med"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197508)36:2 <775::AID-CNCR2820360824>3.0.CO;2-V"},{"key":"e_1_2_1_11_2","first-page":"415","volume-title":"Immunotherapy of Cancer: Present Status of Trails in Man","author":"Gee TS","year":"1977"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950070206"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950040310"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.136.12.1389"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.5904.380"},{"key":"e_1_2_1_16_2","first-page":"96","volume-title":"Clinical Monographs in Hematology I","author":"Necheles TF","year":"1979"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196906)23:6<1296::AID-CNCR2820230609>3.0.CO;2-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90856-2"},{"key":"e_1_2_1_19_2","first-page":"5","article-title":"Assessment of the interrelationship of prognostic factors in childhood acute lymphoblastic leukemia","volume":"2","author":"Robinson LL","year":"1980","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1182\/blood.V55.1.71.71","article-title":"Acute monoblastic leukemia \u2013 A clinical and biologic study of 74 cases","volume":"55","author":"Tobelem G","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000251333"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(70)92874-6"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/ajcp\/56.2.155","article-title":"Acute promyelocytic leukemia with disseminated intravascular coagulation","volume":"56","author":"Pollack A","year":"1971","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_24_2","first-page":"594","volume-title":"Smith's Blood Diseases of Infancy and Childhood","author":"Baehner RL","year":"1978"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950040403"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197909133011109"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1182\/blood.V55.2.253.253","article-title":"Microgranular acute promyelocytic leukemia: A distinct clinical, ultrastructural, and cytogenetic entity","volume":"55","author":"Golomb HM","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_28_2","unstructured":"NesbitM LampkinB BernsteinI KlempererM KerseyJ FeigS KimTH McCreadieS AndersonJ HammondGD:Treatment of newly diagnosed acute nonlymphocytic leukemia with multiagent chemotherapy (cyclic vs continuous) or bone marrow transplantation following total body irradiation. 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