{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:40:39Z","timestamp":1699839639028},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":9331,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serial cytogenetic studies have been performed on a child with Philadelphia chromosome (Ph<jats:sup>1<\/jats:sup>)\u2010positive chronic myelogenous leukemia (CML) and correlated with clinical, morphologic, and cytochemical data in an attempt to elucidate further the natural history of leukemic progression observed in this disease. Once the initial blast crisis had occurred, two genetically different leukemic clones of cells, one presumably having arisen from the other, coexisted throughout the remainder of the patient's course. The initial clone comprised diferentiating myeloid cells, while the second clone appeared on morphologic and cytochemical grounds to be lymphoid and blastic. A dynamic equilibrium existed between these two populations of cells, with the balance altered by chemotherapy and\/or other selective pressures. The leukemic progression demonstrated in this case is consistent with the concept of clonal evolution of malignant cell populations. In planning therapy, it may be necessary to consider each of these coexistent clones and their different therapeutic requirements.<\/jats:p>","DOI":"10.1002\/mpo.2950090509","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:23:32Z","timestamp":1171985012000},"page":"467-472","source":"Crossref","is-referenced-by-count":3,"title":["Coexistence of myeloid and lymphoid neoplastic subpopulations in chronic myelogenous leukemia"],"prefix":"10.1002","volume":"9","author":[{"given":"Raymond J.","family":"Hutchinson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey G.","family":"Rosenstock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Nowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Finan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"1497","article-title":"An innate chromosome in human chronic granulocytic leukemia","volume":"132","author":"Nowell PC","year":"1960","journal-title":"Science"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1182\/blood.V49.5.705.705","article-title":"Characteristics of blast crisis in chronic granulocytic leukemia","volume":"49","author":"Rosenthal S","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90430-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00188.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91939-5"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1182\/blood.V49.4.549.549","article-title":"Ph1\u2010positive childhood leukemias: Spectrum of lymphoid\u2010myeloid expressions","volume":"49","author":"Forman EN","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_8_2","first-page":"459","article-title":"Preleukemia: Cytogenetic clues in some confusing disorders","volume":"89","author":"Nowell PC","year":"1977","journal-title":"Am J Pathol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"776","DOI":"10.4049\/jimmunol.109.4.776","article-title":"Immunoglobulins on the surface of lymphocytes: V. Quantitative studies on the question of whether immunoglobulins are associated with T\u2010cells in the mouse","volume":"109","author":"Grey HM","year":"1972","journal-title":"J Immunol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.2.207"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90199-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197804132981503"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959840"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197812)42:6<2707::AID-CNCR2820420627>3.0.CO;2-5"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950090509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950090509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:02:04Z","timestamp":1699837324000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950090509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1002\/mpo.2950090509"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950090509","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}