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Cyclophosphamide has been reported heretofore to be effective with a minimum of side effects and complications. However, the use of alkylating agents and the induction of a second malignancy is now well recognized. This report describes three cases of refractory ITP treated with cyclophosphamide who subsequently developed an acute non\u2010lymphocytic leukemia. Cyclophosphamide should be used with discretion in the treatment of chronic idiopathic thrombocytopenic purpura which is a non\u2010neoplastic disorder.<\/jats:p>","DOI":"10.1002\/mpo.2950100110","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:22:13Z","timestamp":1171984933000},"page":"61-65","source":"Crossref","is-referenced-by-count":16,"title":["Chronic idiopathic thrombocytopenic purpura (ITP:) development of acute non\u2010lymphocytic leukemia subsequent to treatment with cyclophosphamide"],"prefix":"10.1002","volume":"10","author":[{"given":"John R.","family":"Krause","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.130.5.730"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90016-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.215.3.445"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.140.5.636"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000208825"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1970.tb15536.x"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197408222910802"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197710202971617"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197805182982001"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90781-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830030301"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800315)45:6<1315::AID-CNCR2820450608>3.0.CO;2-F"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1001\/archinte.1979.03630410067021","article-title":"Acute leukemia and immunosuppressive drug use. A review of patients undergoing immunosuppressive therapy for non\u2010neoplastic diseases","volume":"139","author":"Grunwald HW","year":"1979","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197901000-00002"},{"key":"e_1_2_1_16_2","first-page":"2016","article-title":"Myeloblastic leukemia following cyclophosphamide thearpy of plasma cell dyscrasia","volume":"74","author":"Pariser S","year":"1974","journal-title":"NY State J Med"},{"key":"e_1_2_1_17_2","first-page":"759","article-title":"Non\u2010random chromosomal abnormalities in acute non\u2010lymphocytic leukemia in patients treated for Hodgkin's disease and non\u2010Hodgkin's lymphoma","volume":"50","author":"Rowley JD","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90419-2"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950100110","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950100110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T01:26:23Z","timestamp":1699838783000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950100110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/mpo.2950100110"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950100110","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}